| Description | MRT67307isapotentanddualIKKϵandTBK1inhibitorwithIC50of160and19nM,respectively. | ||||||
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| Invitro | Inmacrophages,MRT67307preventsthephosphorylationofIRF3andtheproductionofIFNβ.Inwild-typeMEFs,MRT67307enhancestheIL-1-stimulatedphosphorylationofp105atSer933andRelAatbothSer468andSer536,andalsoenhancesIL-1-stimulatedactivationofNF-κB-dependentgenetranscription.[1]MRT67307increasesIL-10productionandsuppressesproinflammatorycytokineproductionviaacAMPresponseelement-Bindingprotein(CREB)-regulatedtranscriptionalcoactivator(CRTC)3DependentMechanism.[2]Inaddition,MRT67307inhibitULKandblockautophagyinMEFcells.[3] | ||||||
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