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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
| Description | I-CBP112isapotentandselectiveCBP/p300inhibitorwithdissociationconstant(KD)of151±6nMand167±8nMforCBPandp300,respectively. | ||||
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| Targets |
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| Invitro | ExposureofhumanandmouseleukemiccelllinestoI-CBP112resultedinsubstantiallyimpairedcolonyformationandinducedcellulardifferentiationwithoutsignificantcytotoxicity.I-CBP112significantlyreducedtheleukemia-initiatingpotentialofMLL-AF9+AMLcellsinadose-dependentmannerinvitroandinvivo.I-CBP112isanacetyl-lysinecompetitiveinhibitordisplacingH3K56acfromtheCBPbindingsitewithanIC50valueof170nM[1]. |
