DSP-d8deuteratedproteincrosslinker,Dithiobis(succinimidyl2,2,3,3,6,6,7,7-propionate-d8),isacellmembranepermeable,homobifunctional,proteincrosslinkercontaining8deuteriumatomstoprovidean8Daltonshiftbymassspectrometrycomparedtonon-dueteratedDSP(DSP-d₀).DSP-d8deuteratedcrosslinkerhasamine-reactiveNHSestersatbothendsofacleavable,8-atom(12.0angstrom)spacerarm.DSP-d8deuteratedcrosslinkercontainsareducIBLedisulfidebond(SS-bond)inthespacerarmthatmakesitagoodchoicefornumerousapplicationswherereversiblecrosslinkingisdesired.

UsetheheavyDSP-d8deuteratedproteincrosslinkingreagentincombinationwiththelight,non-deuteratedanalog(DSP-d₀)formassspecstudies.

DSP-d8deuteratedcrosslinkermustbedissolvedinanorganicsolvent,suchasDMSOorDMF,andthenmaybeaddedtoanaqueouscrosslinkingreaction.BecauseDSP-d8crosslinkeriscellmembranepermeableitcanbeusedtocrosslinkintracellularproteins.

MolecularWeight:412.46

SpacerLength:12.0Å

Alternativenames:d8-DSP;DSP-d₈;D8-DSP;Dithiobis(succinimidylpropionate-d8);DTSP-d8

References:
Tan,L.,Turecek,F.,Francisco,J.S.,&Xia,Y.(2014).ProbingtheRADIcalandBaseDualPropertiesofPeptideSulfinylRadicalsviaMassSpectrometry.TheJournalofPhysicalChemistryA,118(50),11828-11835.

Rotunno,M.S.,Auclair,J.R.,Maniatis,S.,Shaffer,S.A.,Agar,J.,&Bosco,D.A.(2014).Identificationofamisfoldedregioninsuperoxidedismutase1thatisexposedinamyotrophiclateralsclerosis.JournalofBIOLOGicalChemistry,289(41),28527-28538.

SpecialbulkpricingisavailableforbulkquantitiesofDSP-d8deuteratedcrosslinkerforyourlargevolumemanufacturingapplication. 净化洗涤剂-净化洗涤剂解决方案ProteoChem的纯化洗涤剂水溶液具有超高纯度，低过氧化物含量和低羰基含量。纯化的聚山梨酯20，聚山梨酯80，聚乙二醇十二烷基醚，NP-40，Triton X-100和Triton X-114的10％（w / v）溶液可用于增溶膜蛋白，减少非特异性结合ELISA或IHC，有助于细胞膜裂解和其他蛋白质研究应用。纯化洗涤剂溶液的药物用途包括稳定乳液和悬浮液。ProteoChem的纯化表面活性剂溶液是最好的。它们的稳定性和纯度处于行业领先地位（<1.0 µeq / ml的过氧化物和羰基化合物）。