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商品描述
Specifications
SPECIESREACTIVITY: | Human,Mouse,Rat |
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TESTEDAPPLICATIONS: | WB |
APPLICATIONS: | WesternBlot:1:500~1:1000 |
PREDICTEDMOLECULARWEIGHT: | 18kDa |
SPECIFICITY: | ThisantibodydetectsendogenouslevelofVEGFR2onlywhenphosphorylatedattyrosine1214. |
IMMUNOGEN: | a-Synuclein(Phospho-Ser129)antibodywasraisedagainstapeptidesequencearoundphosphorylationsiteofserine129(M-P-S(p)-E-E)derivedfromHumanα-Synuclein. |
HOSTSPECIES: | Rabbit |
Properties
PURIFICATION: | Antibodieswerepurifiedbyaffinity-chromatographyusingepitope-specificphosphopeptide.Non-phosphospecificantibodieswereremovedbychromatogramphyusingnon-phosphopeptide. |
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PHYSICALSTATE: | Liquid |
BUFFER: | Antibodysuppliedinphosphatebufferedsaline(withoutMg2+andCa2+),pH7.4,150mMNaCl,0.02%sodiumazideand50%glycerol. |
CONCENTRATION: | 1mg/mL |
STORAGECONDITIONS: | Storeantibodyat-20˚Cforuptooneyear. |
CLONALITY: | Polyclonal |
CONJUGATE: | Unconjugated |
AdditionalInfo
ALTERNATENAMES: | PD1,NACP,PARK1,PARK4,ERBB,ERBB1,HER1,SYN,SYUA |
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ACCESSIONNO.: | NP_000336.1 |
PROTEINGINO.: | 4507109 |
OFFICIALSYMBOL: | SNCA |
GENEID: | 6622 |
Background
BACKGROUND: | Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase-3activation. |
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REFERENCES: | 1)TakahashiT,etal.JBiolChem2003Oct24;278(43):42225-33AhnBH,etal.JBiolChem2002Apr05;277(14):12334-42NegroA,etal.FASEBJ2002Feb;16(2):210-2Goldberg,etal.Nat.CellBiol.2000;2,115-119. |