Synonym:PIK39;PIK39;PIK-39.

IUPAC/ChemicalName:2-(((9H-purin-6-yl)thio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one

InChiKey:UMMYTDJYDSTEMB-UHFFFAOYSA-N

InChiCode:InChI=1S/C21H15ClN6O2S/c1-30-15-8-3-2-7-14(15)28-16(27-13-6-4-5-12(22)17(13)21(28)29)9-31-20-18-19(24-10-23-18)25-11-26-20/h2-8,10-11H,9H2,1H3,(H,23,24,25,26)

SMILESCode:O=C1N(C2=CC=CC=C2OC)C(CSC3=C4N=CNC4=NC=N3)=NC5=C1C(Cl)=CC=C5

TechnicalData

AdditionalInformation

References

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5.Thep110δstructure:mechanismsforselectivityandpotencyofnewPI(3)Kinhibitors.[ErratumtodocumentcitedinCA152:375583].ByBerndt,Alex;Miller,Siimon;Williams,Olusegun;Le,DanielD.;Houseman,BenjaminT.;Pacold,JosephI.;Gorrec,Fabrice;Hon,Wai-Chon;Liu,Yi;Rommel,Christian;etal.FromNatureChemicalBiology(2010),6(3),244.,

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10.ApharmacologicalmapofthePI3-Kfamilydefinesaroleforp110αininsulinsignaling.ByKnight,ZacharyA.;Gonzalez,Beatriz;Feldman,MorriE.;Zunder,EliR.;Goldenberg,DavidD.;Williams,Olusegun;Loewith,Robbie;Stokoe,David;Balla,Andras;Toth,Balazs;etal.FromCell(Cambridge,MA,UnitedStates)(2006),125(4),733-747.,DOI:10.1016/j.cell.2006.03.035

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15.Phosphoinositide3-kinaseδselectiveinhibitorsforinhibitingangiogenesis.ByHallahan,Dennis;Hayflick,JoelS.;Sadhu,Chanchal.FromPCTInt.Appl.(2005),WO2005112935A120051201,

16.Phosphoinositide3-kinaseδ-selectiveinhibitorsfortreatingandpreventinghypertensionandhypertension-relateddisorders.ByWatts,StephanieW.;Northcott,CarrieA..FromPCTInt.Appl.(2005),WO2005067901A220050728,

17.MethodsofinhibitingimmuneresponsesstimulatedbyanendogenousfactorbyadmiNISTeringphosphoinositide3-kinaseδselectiveinhibitors.ByDouangpanya,Jason;Hayflick,JoelS.;Puri,KamalD..FromU.S.Pat.Appl.Publ.(2005),US20050043239A120050224,

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