MedKooCat#:401488
Name:GW788388
CAS#:452342-67-5
ChemicalFormula:C25H23N5O2
ExactMass:425.18518
MolecularWeight:425.48242
ElementalAnalysis:C,70.57;H,5.54;N,16.46;O,7.52
Synonym:GW788388;GW-788388;GW788388
IUPAC/ChemicalName:4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide
InChiKey:SAGZIBJAQGBRQA-UHFFFAOYSA-N
InChiCode:InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
SMILESCode:O=C(NC1CCOCC1)C2=CC=C(C3=NC=CC(C4=CNN=C4C5=NC=CC=C5)=C3)C=C2
TechnicalData
AdditionalInformation
References
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3:NomaK,SmalleyKS,LioniM,NaomotoY,TanakaN,El-DeiryW,KingAJ,NakagawaH,HerlynM.Theessentialroleoffibroblastsinesophagealsquamouscellcarcinoma-inducedangiogenesis.Gastroenterology.2008Jun;134(7):1981-93.Epub2008Mar4.PubMedPMID:18439605;PubMedCentralPMCID:PMC2562524.
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5:FrazierK,ThomasR,ScicchitanoM,MirABIleR,BoyceR,ZimmermanD,GrygielkoE,NoldJ,DeGouvilleAC,HuetS,LapingN,GellibertF.InhibitionofALK5signalinginducesphysealdysplasiainrats.ToxicolPathol.2007Feb;35(2):284-95.PubMedPMID:17366323.
6:GellibertF,deGouvilleAC,WoolvenJ,MathewsN,NguyenVL,Bertho-RuaultC,PatikisA,GrygielkoET,LapingNJ,HuetS.Discoveryof4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide(GW788388):apotent,selective,andorallyactivetransforminggrowthfactor-betatypeIreceptorinhibitor.JMedChem.2006Apr6;49(7):2210-21.PubMedPMID:16570917.
