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蚂蚁淘在线 / 品牌中心 / MedKoo / MedKoo Biosciences/KCN1/401515/100mg

MedKoo Biosciences/KCN1/401515/100mg

价格
面议
货号：401515-100mg
浏览量：127
品牌：MedKoo
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商品描述
KCN1,anovelsyntheticsulfonamide,isaHIFpathwayinhibitorwithpotentialanticanceractivityinvitroandinvivoanti-pancreaticcanceractivitiesandpreclinicalpharmacology.KCN1specificallyinhibitedHIFreportergeneactivityinseveralgliomacelllinesatthenanomolarlevel.KCN1alsodownregulatedtranscriptionofendogenousHIF-1targetgenes,suchasVEGF,Glut-1,andcarbonicanhydrase9,inahypoxia-responsiveelement(HRE)-dependentmanner.KCN1potentlyinhibitedthegrowthofsubcutaneousmalignantgliomatumorxenograftswithminimaladverseeffectsonthehost.MechaNISTically,KCN1didnotdownregulatethelevelsofHIF-1αorothercomponentsoftheHIFtranscriptionalcomplex;rather,itantagonizedhypoxia-inducIBLetranscriptionbydisruptingtheinteractionofHIF-1αwithtranscriptionalcoactivatorsp300/CBP.CONCLUSIONS:ThenewHIFpathwayinhibitorKCN1hasantitumoractivityinmousemodels,supportingitsfurthertranslationforthetreatmentofhumantumorsdisplayinghypoxiaorHIFoverexpression(source:ClinCancerRes.2012Nov21.[Epubaheadofprint])

MedKooCat#:401515
Name:KCN1
CAS#:927823-01-6
ChemicalFormula:C26H27NO5S
ExactMass:465.16099
MolecularWeight:465.56
ElementalAnalysis:C,67.08;H,5.85;N,3.01;O,17.18;S,6.89


Synonym:KCN1;KCN-1;KCN1.

IUPAC/ChemicalName:3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide

InChiKey:IPZJNJPAVPZHJM-UHFFFAOYSA-N

InChiCode:InChI=1S/C26H27NO5S/c1-26(2)15-14-20-16-19(10-12-23(20)32-26)18-27(21-8-6-5-7-9-21)33(28,29)22-11-13-24(30-3)25(17-22)31-4/h5-17H,18H2,1-4H3

SMILESCode:O=S(C1=CC=C(OC)C(OC)=C1)(N(CC2=CC(C=CC(C)(C)O3)=C3C=C2)C4=CC=CC=C4)=O


TechnicalData

Appearance:
Solidpowder

Purity:
>98%

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>5yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

   
ThefollowingdatawasfromPLoSOne.2012;7(9):e44883.doi:10.1371/journal.pone.0044883.Epub2012Sep13.
   
  
  
Figure1.InvitroanticanceractivitiesofKCN1againstpancreaticcancercells. (B)CellgrowthinhibitoryactivityofKCN1inhumanpancreaticcancercells.CellswereexposedtovariousconcentrationsofKCN1for72h,followedbyanMTTassay.(Source:PLoSOne.2012;7(9):e44883.doi:10.1371/journal.pone.0044883.Epub2012Sep13.)
Figure1.InvitroanticanceractivitiesofKCN1againstpancreaticcancercells. (B)CellgrowthinhibitoryactivityofKCN1inhumanpancreaticcancercells.CellswereexposedtovariousconcentrationsofKCN1for72h,followedbyanMTTassay.(
)
   
   
     
     


References

1:WangW,AoL,RayburnER,XuH,ZhangX,ZhangX,NagSA,WuX,WangMH,WangH,VanMeirEG,ZhangR.KCN1,anovelsyntheticsulfonamideanticanceragent:invitroandinvivoanti-pancreaticcanceractivitiesandpreclinicalpharmacology.PLoSOne.2012;7(9):e44883.doi:10.1371/journal.pone.0044883.Epub2012Sep13.PubMedPMID:23028659;PubMedCentralPMCID:PMC3441526.

2:YinS,KaluzS,DeviNS,JabbarAA,deNoronhaRG,MunJ,ZhangZ,BoreddyPR,WangW,WangZ,AbbruscatoT,ChenZ,OlsonJJ,ZhangR,GoodmanMM,NicolaouKC,VanMeirEG.ArylsulfonamideKCN1InhibitsInVivoGliomaGrowthandInterfereswithHIFSignalingbyDisruptingHIF-1αInteractionwithCofactorsp300/CBP.ClinCancerRes.2012Nov21.[Epubaheadofprint]PubMedPMID:22923450;PubMedCentralPMCID:PMC3518680.
 
  

我国旅美科学家陈清奇博士创立的MedKoo美帝药库医药公司目前正在建立全球第一个小分子抗癌药库。 MedKoo是一家以研发、生产和销售小分子抗癌化合物为主的医药科技公司。 业务范围 为全球所有从事抗癌药物研究和开发的制药公司，高校，研究院所，政府相关机构提供与抗癌药物分子相关的产品、试剂和技术服务。 技术核心 以药物化学合成技术为核心，密切结合全球抗癌新药研发领域中的新技术、新理论、新趋势和新的发展方向，不断推出抗癌化合物新品种。 建造目标 MedKoo美帝药库的目标是：建成全球最大的小分子抗癌药库 ，品种最多最全、质量最好最可靠。美帝药库的宗旨是：客户第一；质量第一；信誉第一；创新第一。