| Description | Ceruletide(Caerulein)isabiologicallyactivedecapeptideisolatedfromtheskinoftheAustralianfrogHylacaerulea.Itisapotentcholecystokineticagentwithadirectspasmogeniceffectonthegallbladdermuscleandbileductsinhumansand |
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| InVitro | Ceruletideissimilarchemicallyandbiologicallytothehumangastrointestinalhormonescholecystokinin-pancreozymin(CCK)andgastrinII.Ceruletidestimulatesgallbladdercontraction,pancreaticexocrinesecretion,gastricsecretion,andmotilityinthedistalduodenum,jejunum,ileumandcolon,whiledelayinggastricemptyingandinhibitingmotilityintheproximalduodenum[1].NF-kappaB/Relisrapidlyactivatedduringceruleinpancreatitis.Thisactivationmayinduceaself-defendinggeneticprogrambeforetheonsetofcellularinjury,whichmightpreventhigherdegreesofdamageofpancreaticacinarcellsaftersecretagoguehyperstimulation[2]. |
| References |
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| MolecularWeight | 1352.41 | ||||||||||||
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| Formula | C₅₈H₇₃N₁₃O₂₁S₂ | ||||||||||||
| CASNo. | 17650-98-5 | ||||||||||||
| Storage |
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| Shipping | RoomtemperatureincontinentalUS;mayvaryelsewhere | ||||||||||||
| Solvent&Solubility | H2O:≥100mg/mL *"<1 mg/ml"="" means="" slightly="" soluble="" or="" insoluble.="" "≥"="" means="" soluble,="" but="" saturation=""> Purity:99.59% |
