Catalog#:1918

ScientificName:N-Docosanoyl-D-erythro-sphingosylphosphorylcholine

CommonName:N-C22:0-Sphingomyelin

EmpiricalFormula:C₄₅H₉₁N₂O₆P

SDSViewSafetyDataSheet

DataSheet:ViewDataSheet

FormulaWeight:787

Unit:500µg

Solvent:none

Source:semisynthetic

Purity:98+%

AnalyticalMethods:TLC,identityconfirmedbyMS

NaturalSource:bovinebuttermilk

Solubility:ethanol,methanol,chloroform/methanol,14:1

PhysicalAppearance:solid

Storage:-20°C

DryIce:No

Hazardous:No

LiteratureReferences:
1.R.N.Kolesnick,A.Haimovitz-Friedman,Z.Fuks“Thesphingomyelinsignaltransductionpathwaymediatesapoptosisfortumornecrosisfactor,Fas,andionizingrADIation”BiochemCellBiol.,Vol.72(11-12)pp.471-474,1994
2.M.Schmuth,etal.“PermeABIlitybarrierdisorderinNiemann-Pickdisease:sphingomyelin-ceramideprocessingrequiredfornormalbarrierhomeostasis”JInvestDermatol.,Vol.115(3)pp.459-466,2000
3.C.StClairetal.“Theprobabilityofneonatalrespiratorydistresssyndromeasafunctionofgestationalageandlecithin/sphingomyelinratio”AmJPerinatol.,Vol.25(8)pp.473-480,2008,
4.J.Kilkusetal.“Differentialregulationofsphingomyelinsynthesisandcatabolisminoligodendrocytesandneurons”JNeuRochem.Vol.106(4)pp.1745-1757,2008
5.N.DuanRD.“Absorptionandlipoproteintransportofsphingomyelin”JLipidRes.,Vol.47(1)pp.154-171,2006
6.R.Veldmanetal.“N-hexanoyl-sphingomyelinpotentiatesinvitrodoxorubicincytotoxicitybyenhancingitscellularinflux”Nature,vol.90pp.917-925,2004

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