Description
Hydrocortisone is a steroid hormone that is produced in the adrenal cortex and is involved in stress signaling. Hydrocortisone is a glucocorticoid and is also known as cortisol in its endogenous form; it exhibits anti-inflammatory and immunomodulatory activities. Hydrocortisone is clinically used to treat eczema, psoriasis, gout, and severe allergic reactions. Hydrocortisone stimulates gluconeogenesis, inhibits inflammatory cytokine production, and shifts the immune response from Th1 to Th4 subtype.
References
Angelier F, Wingfield JC. Importance of the glucocorticoid stress response in a changing world: theory, hypotheses and perspectives. Gen Comp Endocrinol. 2013 Sep 1;190:118-28. PMID: 23770214.
Tarchalska-Kryńska B. Glucocorticosteroids: mechanism of action, pharmacological effects, pharmacokinetics and adverse effects. Otolaryngol Pol. 1994;48 Suppl 17:41-8. PMID: 8090502.
Sluyser M. Mechanism of steroid hormone action at the cellular level. Basic Life Sci. 1975;6:79-104. PMID:168860.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
