Description
GDC-0623 is an inhibitor of MEK that prevents MEK-dependent B-Raf and KRAS signaling. GDC-0623 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for several cancers.
GDC-0623 is an inhibitor of MEK that prevents MEK-dependent B-Raf and KRAS signaling. GDC-0623 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for several cancers.
Cas No. | 1168091-68-6 |
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Purity | ≥98% |
Formula | C16H14FIN4O3 |
Formula Wt. | 456.21 |
IUPAC Name | 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide |
Appearance | Beige Powder |
Store Temp | 4°C |
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Ship Temp | Ambient |
Info Sheet | G1210 Info Sheet PDF |
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Brochures | Ras-Raf-MEK-ERK Pathway Booklet |
Hatzivassiliou G, Haling JR, Chen H, et al. Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers. Nature. 2013 Sep 12;501(7466):232-6. PMID: 23934108.
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