Cisplatin is a platinum-based cross-linking agent that exhibits anticancer chemotherapeutic activity. Cisplatin induces crosslinks between guanine bases on DNA; it is clinically used to treat various forms of cancer. In lung cancer cells, cisplatin decreases phosphorylation of PI3K, Akt, and FOXO3a and induces apoptosis. Additionally, cisplatin modulates STAT signaling and immune responses in other models.
| Cas No. | 15663-27-1 |
|---|---|
| Purity | ≥98% |
| Formula | Cl2H6N2Pt |
| Formula Wt. | 300.04 |
| Chemical Name | cis-Dichlorodiammine platinum(II) |
| Synonym | Abiplatin; DDP; Platiblastin; cis- Dichlorodi- ammineplatinum |
| Melting Point | 270°C (dec.) |
| Solubility | Slightly soluble in water. DMSO to 60mg/mL |
| Appearance | Glassy yellow or orange, yellow crystalline powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | C3374 MSDS PDF |
|---|---|
| Info Sheet | C3374 Info Sheet PDF |
Hato SV, Khong A, de Vries IJ, et al. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014 Jun 1;20(11):2831-7. PMID: 24879823.
Liu H, Yin J, Wang C, et al. FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 2014 Sep;25(8):898-907. PMID: 24814195.
Stordal B, Davey M. Understanding cisplatin resistance using cellular models. IUBMB Life. 2007 Nov;59(11):696-9. PMID: 17885832.
Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.
