Glycoprotein 38 (gp38) is a transmembrane O-glycoprotein that maintains barrier function in high endothelial venules. In development, gp38 activates platelets to induce separation of lymphatic and blood vascular systems. Additionally, gp38 may exhibit carcinogenic/tumorigenic activity, as it promotes cell motility via PKA signaling and is used as a biomarker to detect various cancers.
| Purity | ≥95% |
|---|---|
| Formula | C133H209N41O38S2 |
| Formula Wt. | 3054.53 |
| Synonym | Podoplanin; gp38 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G6000 Info Sheet PDF |
|---|
Herzog BH, Fu J, Wilson SJ, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 3;502(7469):105-9. PMID: 23995678.
Krishnan H, Ochoa-Alvarez JA, Shen Y, et al. Serines in the intracellular tail of podoplanin (PDPN) regulate cell motility. J Biol Chem. 2013 Apr 26;288(17):12215-21. PMID: 23530051.
Konishi S, Yasuchika K, Ishii T, et al. A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers. In Vitro Cell Dev Biol Anim. 2011 Jan;47(1):45-53. PMID: 21104040.
Uhrin P, Zaujec J, Breuss JM, et al. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010 May 13;115(19):3997-4005. PMID: 20110424.
