Description
Neuropeptide FF is an endogenous RF amide family peptide that exhibits anti-inflammatory and anti-analgesic activities. Neuropeptide FF binds NPFF1/2 receptors in the brain, regulating blood pressure and hormone secretion. In LPS-stimulated macrophages, neuropeptide FF decreases NO production and inhibits NF-κB translocation; in animal models, it suppresses carrageenan-induced edema. Additionally, neuropeptide FF inhibits opioid-induced stress-mediated analgesia in the forced swim test, displaying anti-opioid activity.
References
Sun YL, Zhang XY, Sun T, et al. The anti-inflammatory potential of neuropeptide FF in vitro and in vivo. Peptides. 2013 Sep;47:124-32. PMID: 23856454.
Jhamandas JH, Goncharuk V. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8. PMID: 23404625.
Li N, Han ZL, Fang Q, et al. Neuropeptide FF and related peptides attenuates warm-, but not cold-water swim stress-induced analgesia in mice. Behav Brain Res. 2012 Aug 1;233(2):428-33. PMID: 22659392.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
