Description
Methyl salicylate can be found in Spiraea, Betula, and Gaultheria; it exhibits analgesic activity. Methyl salicylate is commercially used as an antiseptic, a wintergreen flavorant/tastant, and as a fragrance. In vitro, methyl salicylate displays both agonist and antagonist activity at transient receptor potential vanilloid 1 (TRPV1) channels. Metabolites of methyl salicylate exhibit anti-inflammatory and analgesic activities in vivo similar to those displayed by most non-steroidal anti-inflammatory drugs (NSAIDs).
References
Tieman D, Zeigler M, Schmelz E, et al. Functional analysis of a tomato salicylic acid methyl transferase and its role in synthesis of the flavor volatile methyl salicylate. Plant J. 2010 Apr 1;62(1):113-23. PMID: 20070566.
Ohta T, Imagawa T, Ito S. Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate. Mol Pharmacol. 2009 Feb;75(2):307-17. PMID: 18987162.
James DG, Price TS. Field-testing of methyl salicylate for recruitment and retention of beneficial insects in grapes and hops. J Chem Ecol. 2004 Aug;30(8):1613-28. PMID: 15537163.
Mason L, Moore RA, Edwards JE, et al. Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain. BMJ. 2004 Apr 24;328(7446):995. PMID: 15033879.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
