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蚂蚁淘在线 / 品牌中心 / LKT Labs / LKT/CLODRONATE DISODIUM TETRAHYDRATE/C3449/100 mg

LKT/CLODRONATE DISODIUM TETRAHYDRATE/C3449/100 mg

价格
￥9680.00
货号：C3449-100mg
浏览量：122
品牌：LKT Labs
服务
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商品描述
ProductIDC3449
CasNo.88416-50-6
Purity≥98%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

Clodronateisafirst-generationnon-nitrogen-containingbisphosphonatethatisusedclinicallyforitsanti-resorptiveactivity.Clodronategeneratesformationofanon-hydrolysableβ-γATPanalogthatinhibitsmitochondrialADP/ATPtranslocaseandpreventsmitochondrialoxygenconsumptionandfunction;asaresult,osteoblastcalciumdepositionisinhibitedandapoptosisisinducedinosteoclasts,inhibitingboneresorption.ClodronatealsodecreasesexpressionofMMP9andimprovesperformanceontheRotarodtest,decreasingseverityofexperimentalautoimmuneneuritis,ananimalmodelofGuillan-BarreSyndrome.Additionally,clodronateexhibitsanticancerchemotherapeuticandanti-angiogenicactivities,decreasingvesseldensityinvivoandinhibitingcellularproliferationinmodelsofrenalcellcarcinoma.

ProductInfo

CasNo.

88416-50-6

Purity

≥98%

Formula

CH2Cl2Na2O6P2•4H2O

FormulaWt.

360.92

ChemicalName

Clodronatedisodiumsalt;Dichloromethylene-bisphophonatedisodiumtetrahydrate

IUPACName

disodium;[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

Synonym

Clodronicaciddisodiumsalt,chlodronatesodium,clasteron

Solubility

Solubleinwaterto100mM

Appearance

WhiteCrystalPowder

ShippingandStorage

StoreTemp

Ambient

ShipTemp

Ambient

Downloads

MSDS

C3449MSDSPDF

InfoSheet

C3449InfoSheetPDF

References

KatzavA,BinaH,AronovichR,etal.Treatmentforexperimentalautoimmuneneuritiswithclodronate(Bonefos).ImmunolRes.2013Jul;56(2-3):334-40.PMID:23579773.

SoltauJ,ZirrgiebelU,EsserN,etal.AntitumoralandantiangiogenicefficacyofbisphosphonatesinvitroandinamurineRENCAmodel.AnticancerRes.2008Mar-Apr;28(2A):933-41.PMID:18507039.

KellinsalmiM,MönkkönenH,MönkkönenJ,etal.Invitrocomparisonofclodronate,pamidronateandzoledronicacideffectsonratosteoclastsandhumanstemcell-derivedosteoblasts.BasicClinPharmacolToxicol.2005Dec;97(6):382-91.PMID:16364054.

ReszkaAA,RodanGA.Mechanismofactionofbisphosphonates.CurrOsteoporosRep.2003Sep;1(2):45-52.PMID:16036064.

RogersMJ.Newinsightsintothemolecularmechanismsofactionofbisphosphonates.CurrPharmDes.2003;9(32):2643-58.PMID:14529538.

LehenkariPP,KellinsalmiM,NäpänkangasJP,etal.Furtherinsightintomechanismofactionofclodronate:inhibitionofmitochondrialADP/ATPtranslocasebyanonhydrolyzable,adenine-containingmetabolite.MolPharmacol.2002May;61(5):1255-62.PMID:11961144.

SatoA,NakashimaH,NakashimaM,etal.InvolvementoftheTNFandFasLproducedbyCD11bKupffercells/macrophagesinCCl4-inducedacutehepaticinjury.PLoSOne.2014Mar25;9(3):e92515.PMID:24667392.

KimuraK,NakamuraY,InabaY,etal.Histidineaugmentsthesuppressionofhepaticglucoseproductionbycentralinsulinaction.Diabetes.2013Jul;62(7):2266-2277.PMID:23474485.

ABOUT LKT LABS LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.