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蚂蚁淘在线 / 品牌中心 / LKT Labs / LKT/CH5424802/C2900/10 mg

LKT/CH5424802/C2900/10 mg

价格
￥5320.00
货号：C2900-10mg
浏览量：127
品牌：LKT Labs
服务
全国联保
正品保证
正规发票
签订合同
商品描述
ProductIDC2900
CasNo.1256580-46-7
Purity≥99%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

CH5424802isaninhibitorofanaplasticlymphomakinase(ALK)thatdisplaysanticancerchemotherapeuticandanti-metastaticactivitiesagainstWTandL1196MmutantALK.Thiscompoundisinclinicaltrialsasapotentialtreatmentforvariouscancers.CH5424802inducesregressionofnon-smallcelllungcancer(NSCLC)cellmetastasisinthebraininvivo,increasingsurvivalrates.Thiscompounddisplaysefficacyinsubjectsresistanttocrizotanib.

ProductInfo

CasNo.

1256580-46-7

Purity

≥99%

Formula

C30H34N4O2

FormulaWt.

482.62

Synonym

CH5424802,Alectinib

Appearance

Whitetooffwhitepowder

ShippingandStorage

StoreTemp

-20°C

ShipTemp

Ambient

Downloads

InfoSheet

C2900InfoSheetPDF

References

SantarpiaM,AltavillaG,RosellR.Alectinib:aselective,next-generationALKinhibitorfortreatmentofALK-rearrangednon-small-celllungcancer.ExpertRevRespirMed.2015Feb5:1-14.[Epubaheadofprint].PMID:25652176.

KodamaT,HasegawaM,TakanashiK,etal.AntitumoractivityoftheselectiveALKinhibitoralectinibinmodelsofintracranialmetastases.CancerChemotherPharmacol.2014Nov;74(5):1023-8.PMID:25205428.

KodamaT,TsukaguchiT,YoshidaM,etal.SelectiveALKinhibitoralectinibwithpotentantitumoractivityinmodelsofcrizotinibresistance.CancerLett.2014Sep1;351(2):215-21.PMID:24887559.

RossiA,MaioneP,SaccoPC,etal.ALKinhibitorsandadvancednon-smallcelllungcancer(review).IntJOncol.2014Aug;45(2):499-508.PMID:24889366.

ABOUT LKT LABS LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.