Description
Rasagiline is an inhibitor of monoamine oxidase B (MAO-B) that is used to treat Parkinson’s disease. Rasagiline may also exhibit effects on MAO-A, as actions on that enzyme are likely responsible for the ability of rasagiline to increase levels of Bcl-2, glial cell line-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF). Rasagiline also displays neuroprotective activity, inhibiting mitochondrial membrane permeability, preventing caspase- and mitochondria-mediated apoptosis.
References
Naoi M, Maruyama W, Inaba-Hasegawa K. Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms. Expert Rev Neurother. 2013 Jun;13(6):671-84. PMID: 23739004.
Naoi M, Maruyama W, Yi H. Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria. J Neural Transm. 2013 Nov;120(11):1539-51. PMID: 23681678.
Inaba-Hasegawa K, Akao Y, Maruyama W, et al. Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase. J Neural Transm. 2012 Apr;119(4):405-14. PMID: 22065207.
Weinreb O, Amit T, Bar-Am O, et al. Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy. Ann N Y Acad Sci. 2007 Dec;1122:155-68. PMID: 18077571.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
