Description
Prednisone is a synthetic corticosteroid/glucocorticoid that exhibits no biological activity until converted to its active metabolite, prednisolone. Once converted, this compound exhibits anti-inflammatory, immunosuppressive, anti-allergic, neuroprotective, and anticancer chemotherapeutic activities. Prednisone is one component of the CHOP chemotherapeutic cocktail that is clinically used to treat leukemias and lymphomas; in animal models of subarachnoid hemorrhage, CHOP inhibits neuronal apoptosis. Prednisone also inhibits expression of IL-6 and is clinically used to treat rheumatoid arthritis.
References
Hoy SM. Bendamustine: a review of its use in the management of chronic lymphocytic leukaemia, rituximab-refractory indolent non-Hodgkin's lymphoma and multiple myeloma. Drugs. 2012 Oct 1;72(14):1929-50. PMID: 22950536.
Clarke L, Kirwan J. Efficacy, safety and mechanism of action of modified-release prednisone in rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):159-66. PMID: 22850902.
He Z, Ostrowski RP, Sun X, et al. CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage. Stroke. 2012 Feb;43(2):484-90. PMID: 22180248.
Manns MP, Strassburg CP. Therapeutic strategies for autoimmune hepatitis. Dig Dis. 2011;29(4):411-5. PMID: 21894012.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
