Description
Dextromethorphan exhibits anti-tussive, hallucinogenic, neuromodulatory, neuroprotective, anticonvulsant/antiepileptic, and anti-osteoporotic activities. Dextromethorphan acts as a full antagonist at serotonin transporters (SERTs), norepinephrine transporters (NETs), α3β4, α4β2, and α7 nicotinic acetylcholine receptors (nAChRs), and NADPH oxidase; it also acts as a weak antagonist at NMDA receptors. Additionally, dextromethorphan acts as a full agonist at σ1/2 receptors and as a weak agonist at μ/κ/δ opioid receptors. Dextromethorphan is commonly used in over-the-counter cough medicines. In animal models of Parkinson’s disease, dextromethorphan inhibits endotoxin-induced dopaminergic neurodegeneration. In electroshock assays, this compound inhibits the development of seizures. Dextromethorphan also inhibits RANKL-induced osteoclastogenesis and prevents bone loss in vivo. CHECK BUYER INFO – THIS PRODUCT HAS BEEN KNOWN FOR RECREATIONAL USE.
References
Burns JM, Boyer EW. Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. PMID: 24648790.
Wu K, Lin TH, Liou HC, et al. Dextromethorphan inhibits osteoclast differentiation by suppressing RANKL-induced nuclear factor-κB activation. Osteoporos Int. 2013 Aug;24(8):2201-14. PMID: 23400250.
Damaj MI, Flood P, Ho KK, et al. Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity. J Pharmacol Exp Ther. 2005 Feb;312(2):780-5. PMID: 15356218.
Zhang W, Wang T, Qin L, et al. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. FASEB J. 2004 Mar;18(3):589-91. PMID: 14734632.
Chou YC, Liao JF, Chang WY, et al. Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 1999 Mar 13;821(2):516-9. PMID: 10064839.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
