Description
Polydatinisaresveratrol-relatedglucosideoriginallyfoundinPolygonumcUSPidatum.Polydatinexhibitsanticancer,anti-inflammatory,antioxidative,andanti-allergicactivities.Inlungcancercells,polydatindownregulatesexpressionofcyclinD1andBcl-2andupregulatesexpressionofBax,inducingcellcyclearrestandapoptosis.Inanimalmodelsofsepsis,polydatindecreasessepsis-inducedmortalityandlunginjurybysuppressingproductionofCOX-2,iNOS,andinflammatorycytokines.PolydatinalsodecreasesthelossofmucosalbarrierintegrityinthesmallintestineduetoOVA-inducedallergybyinhibitingmastcelldegranulation.
References
ZhangY,ZhuangZ,MengQ,etal.Polydatininhibitsgrowthoflungcancercellsbyinducingapoptosisandcausingcellcyclearrest.OncolLett.2014Jan;7(1):295-301.PMID:24348867.
YangB,LiJJ,CaoJJ,etal.Polydatinattenuatedfoodallergyviastore-operatedcalciumchannelsinmastcell.WorldJGastroenterol.2013Jul7;19(25):3980-9.PMID:23840142.
LiXH,GongX,ZhangL,etal.ProtectiveeffectsofpolydatinonsepticlunginjuryinmiceviaupregulationofHO-1.MediatorsInflamm.2013;2013:354087.PMID:23431240.
WuMJ,GongX,JiangR,etal.Polydatinprotectsagainstlipopolysaccharide-inducedfulminanthepaticfailureinD-galactosamine-sensitizedmice.IntJImmunopatholPharmacol.2012Oct-Dec;25(4):923-34.PMID:23298483.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
