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LKT/LAPPACONITINE/L0060/500 mg

价格
¥23140.00
货号:L0060-500mg
浏览量:76
品牌:LKT Labs
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商品描述
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Lappaconitine is an alkaloid originally found in species of Aconitum that exhibits analgesic, antinociceptive, anti-inflammatory, anti-arrhythmic, and antiepileptic/anticonvulsant activities. Lappaconitine increases pain threshold and downregulates expression of P2X3 receptors in dorsal root ganglion (DRG) neurons in models of chronic constrictive injury. Lappaconitine also inhibits paw and ear edema in vivo. In vitro, this compound inhibits excitability of hippocampal pyramidal cells and decreases epileptiform burst duration. Additionally, lappaconitine displays class I anti-arrhythmic activity, inducing negative inotropic activity in vivo and inhibiting human heart Na+ channels by binding at neurotoxin site 2.

Product Info

Cas No.

32854-75-4

Purity

≥98%

Formula

C32H44N2O8

Formula Wt.

584.70

Chemical Name

(1α,14α,16β)-20-Ethyl-1,14,16-trimethoxyaconitane- 4,8,9-triol 4-[2-(acetylamino)-benzoate]

Synonym

(+)-Lappaconitine

Melting Point

217-218°C

Solubility

Soluble in benzene. Slightly soluble in alcohol and ether. Practically insoluble in water.

Appearance

Almost White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

Info Sheet

L0060 Info Sheet PDF

References

Ou S, Zhao YD, Xiao Z, et al. Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion. Neurochem Int. 2011 Apr;58(5):564-73. PMID: 21272608.

Wang YZ, Xiao YQ, Zhang C, et al. Study of analgesic and anti-inflammatory effects of lappaconitine gelata. J Tradit Chin Med. 2009 Jun;29(2):141-5. PMID: 19663103.

Wright SN. Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol. 2001 Feb;59(2):183-92. PMID: 11160852.

Heubach JF, Schüle A. Cardiac effects of lappaconitine and N-deacetyllappaconitine, two diterpenoid alkaloids from plants of the Aconitum and Delphinium species. Planta Med. 1998 Feb;64(1):22-6. PMID: 9491764.

Ameri A, Gleitz J, Peters T. Bicuculline-induced epileptiform activity in rat hippocampal slices: suppression by Aconitum alkaloids. Planta Med. 1997 Jun;63(3):228-32. PMID: 9225604.

ABOUT LKT LABS LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.