Description
Fluticasone is an agonist at β2-adrenergic receptors that is clinically used to treat asthma and COPD; it exhibits anti-inflammatory, vasodilatory, anti-asthma, and anti-allergic activities. In airway epithelial cells, fluticasone increases expression of IκB kinase, preventing activation of NF-κB. In other in vitro models, fluticasone decreases lymphocyte activation, particularly mast cell activation, and decreases IL-6 levels. In animal models, fluticasone upregulates Smad7 and downregulates phospho-Smad2/3 and TGF-β1 levels, preventing eosinophilic inflammation and airway remodeling.
References
Kan-O K, Matsumoto K, Inoue H, et al. Corticosteroids plus long-acting β2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium. Int Arch Allergy Immunol. 2013;160(1):27-36. PMID: 22948082.
Mendes ES, Horvath G, Campos M, et al. Rapid corticosteroid effect on beta(2)-adrenergic airway and airway vascular reactivity in patients with mild asthma. J Allergy Clin Immunol. 2008 Mar;121(3):700-4. PMID: 18086493.
Lee SY, Kim JS, Lee JM, et al. Inhaled corticosteroid prevents the thickening of airway smooth muscle in murine model of chronic asthma. Pulm Pharmacol Ther. 2008;21(1):14-9. PMID: 17142077.
Edwards MR, Haas J, Panettieri RA Jr, et al. Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. J Biol Chem. 2007 May 25;282(21):15366-75. PMID: 17395587.
Booth H, Richmond I, Ward C, et al. Effect of high dose inhaled fluticasone propionate on airway inflammation in asthma. Am J Respir Crit Care Med. 1995 Jul;152(1):45-52. PMID: 7599861.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
