Description
Glucosamine is an endogenous amino sugar precursor to glycosylated protein and lipid formation; it is used in the making of cartilage. Glucosamine improves joint function and is often found in dietary supplements. Glucosamine exhibits anticancer and anti-fibrotic activities. In prostate cancer cells, glucosamine decreases N-glycosylation of gp130, suppressing binding of IL-6, phosphorylation of JAK2, SHP2, and STAT3, and cellular proliferation. Additionally, glucosamine decreases TGF-β1-induced expression of collagen I, fibronectin, and αSMA, inhibits phosphorylation of Smad2/3, and suppresses the development of renal fibrosis in vivo.
References
Chesnokov V, Gong B, Sun C, et al. Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation. Cancer Cell Int. 2014 May 28;14:45. PMID: 24932134.
Park J, Lee SY, Ooshima A, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. PMID: 24072041.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
