Description
Ginkgolide A is a terpene lactone found in Ginkgo that exhibits neuroprotective, anti-angiogenic, neuromodulatory, and anxiolytic activities. In cellular models of Alzheimer’s disease, ginkgolide A decreases phosphorylation of tau protein, inhibits GSK-3β, and increases phosphorylation of PI3K/Akt. Ginkgolide A may also act as an agonist at the pregnane X receptor (PXR). This compound inhibits proliferation and migration in vitro and decreases superoxide anion levels, preventing neointimal hyperplasia. In the elevated plus maze test, ginkgolide A increases time spent in open arms.
References
Chen Y, Wang C, Hu M, et al. Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells. Planta Med. 2012 Aug;78(12):1337-41. PMID: 22700047.
Weakley SM, Wang X, Mu H, et al. Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 2011 Nov;171(1):31-9. PMID: 21571322.
Lau AJ, Yang G, Rajaraman G, et al. Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. J Pharmacol Exp Ther. 2010 Dec;335(3):771-80. PMID: 20739453.
Kuribara H, Weintraub ST, Yoshihama T, et al. An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice. J Nat Prod. 2003 Oct;66(10):1333-7. PMID: 14575433.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
