Description
Thymopentin is a five amino acid peptide fragment of thymopoietin that exhibits immunostimulatory and anticancer activities. Thymopentin decreases iNOS activity in the treatment of Sezary Syndrome, a severe form of lymphoma. In leukemia cells, thymopentin inhibits proliferation and colony formation and induces differentiation. In macrophages, thymopentin increases pro-inflammatory cytokine secretion, activation of NF-κB, production of HSP72, and signaling by JNK. Thymopentin shows clinical benefit when used as an adjuvant, improving the response rate in subjects administered hepatitis B vaccines.
References
Patruno A, Tosco P, Borretto E, et al. Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients. Nitric Oxide. 2012 Oct 15;27(3):143-9. PMID: 22721692.
Lunin SM, Glushkova OV, Khrenov MO, et al. Thymus peptides regulate activity of RAW 264.7 macrophage cells: inhibitory analysis and a role of signal cascades. Expert Opin Ther Targets. 2011 Dec;15(12):1337-46. PMID: 22148922.
Fan YZ, Chang H, Yu Y, et al. Thymopentin (TP5), an immunomodulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta. 2006 Oct;1763(10):1059-66. PMID: 16952408.
Fabrizi F, Dixit V, Martin P. Meta-analysis: the adjuvant role of thymopentin on immunological response to hepatitis B virus vaccine in end-stage renal disease. Aliment Pharmacol Ther. 2006 Jun 1;23(11):1559-66. PMID: 16696803.
ABOUT LKT LABS
LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
