Cardiogenol C induces cardiomyogenic effects in pluripotent P19 embryonic carcinoma cells. Cardiogenol C also significantly increases atrial natriuretic factor and Nkx2.5 expression and induces expression of cardiac Nav1.5 channels in C2C12 skeletal myoblasts. In multipotent stem cells from murine hair follicles, Cardiogenol C has also been shown to induce transdifferentiation into cardiomyocyte-like cells.
| Cas No. | 671225-39-1 |
|---|---|
| Purity | ≥98% |
| Formula | C13H16N4O2 • HCl |
| Formula Wt. | 296.76 |
| Chemical Name | 2-({2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl}amino)ethanol hydrochloride |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C0369 Info Sheet PDF |
|---|
Mike AK, Koenig X, Koley M, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-221. PMID: 24481283.
Skalova S, Svadlakova T, Qureshi WMS, et al. Induced pluripotent stem cells and their use in cardiac and neural regenerative medicine. Int J Mol Sci. 2015 Feb;16(2):4043-4067. PMID: 25689424.
Christ GJ, Saul JM, Furth ME, Andersson KE. The pharmacology of regenerative medicine. Pharmacol Rev. 2013 Jul;65(3):1091-1133. PMID: 23818131.
Yau W, Tang MK, Chen E, et al. Cardiogenol C can induce mouse hair bulge progenitor cells to transdifferentiate into cardiomyocyt-like cells. Proteome Sci. 2011;9:3. PMID: 21247432.
