Description
A-779isaninhibitoroftheMasreceptor.Onitsown,A-779hasnoBIOLOGicalactivity;however,throughbindingtheMasreceptor,itinhibitsangiotensin(1-7)signaling(preventingvasodilationandinsulinsensitization)andinhibitssomedownstreaminsulinsignaling.
A-779isaninhibitoroftheMasreceptor.Onitsown,A-779hasnoBIOLOGicalactivity;however,throughbindingtheMasreceptor,itinhibitsangiotensin(1-7)signaling(preventingvasodilationandinsulinsensitization)andinhibitssomedownstreaminsulinsignaling.
CasNo. | 159432-28-7 |
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Purity | ≥95% |
Formula | C39H60N12O11 |
FormulaWt. | 872.99 |
IUPACName | L-α-Aspartyl-N5-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine |
Appearance | Whitetooffwhitepowder |
StoreTemp | -20°C |
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ShipTemp | Ambient |
MSDS | A0099MSDSPDF |
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InfoSheet | A0099InfoSheetPDF |
TaoX,FanJ,KaoG,etal.Angiotensin-(1-7)attenuatesangiotensinII-inducedsignalingassociatedwithactivationofatyrosinephosphataseinSprague-Dawleyratscardiacfibroblasts.BiolCell.2014Mar18.[Epubaheadofprint].PMID:24641355.
SantosRA,Campagnole-SantosMJ,BarachoNC,etal.CharacterizationofanewangiotensinantagoNISTselectiveforangiotensin-(1-7):evidencethattheactionsofangiotensin-(1-7)aremediatedbyspecificangiotensinreceptors.BrainResBull.1994;35(4):293-8.PMID:7850477.
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