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LKT/VIDARABINE/V3212/500 mg

价格
¥2680.00
货号:V3212-500mg
浏览量:73
品牌:LKT Labs
服务
全国联保
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商品描述
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

VidarABIneisalong-actingantiviraloriginallyfoundinthemarinespongeTethyracrypta.VidarabineisanadenosineanaloginwhichtheD-riboseconstituentisreplacedbyD-arabinose,preventingformationofphosphodiesterbridgesuponincorporationintoDNA.ThiscompoundisasubstrateforandinhibitorofviralDNApolymeraseandmayalsoinhibitribonucleotidereductase.VidarabineisusedtotreatsubjectswithseverechronicEpstein-Barrvirus,herpessimplexvirus,orhumanpapillomavirus,aswellasimmunocompromisedpatientswithadenovirus-inducedhemorrhagiccystitis.

ProductInfo

CasNo.

5536-17-4

Purity

≥98%

Formula

C10H13N5O4

FormulaWt.

267.24

ChemicalName

9-β-D-Aribinofuranosyl-9H-purine-6-aminemonohydrate

IUPACName

(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Synonym

Arabinosyladenine;AdenineArabinoside;Spongoadenosine;Ara-A;Arasena-A;Vira-A

MeltingPoint

257-257.5°C

Appearance

WhiteCrystalPowder

ShippingandStorage

StoreTemp

-20°C

ShipTemp

Ambient

Downloads

MSDS

V3212MSDSPDF

InfoSheet

V3212InfoSheetPDF

References

WhitleyRJ.Theuseofantiviraldrugsduringtheneonatalperiod.ClinPerinatol.2012Mar;39(1):69-81.PMID:22341538.

WilhelmusKR.Antiviraltreatmentandothertherapeuticinterventionsforherpessimplexvirusepithelialkeratitis.CochraneDatabaseSystRev.2010Dec8;(12):CD002898.PMID:21154352.

SagarS,KaurM,MinnemanKP.Antiviralleadcompoundsfrommarinesponges.MarDrugs.2010Oct11;8(10):2619-38.PMID:21116410.

KurosakiK,MiwaN,YoshidaY,etal.Therapeuticbasisofvidarabineonadenovirus-inducedhaemorrhagiccystitis.AntivirChemChemother.2004Sep;15(5):281-5.PMID:15535050.

NiwaK,TagamiK,LianZ,etal.Topicalvidarabineor5-fluorouraciltreatmentagainstpersistentHPVingenital(pre)cancerouslesions.OncolRep.2003Sep-Oct;10(5):1437-41.PMID:12883720.

KimuraH,MoritaM,TsugeI,etal.VidarabinetherapyforseverechronicactiveEpstein-Barrvirusinfection.JPediatrHematolOncol.2001Jun-Jul;23(5):294-9.PMID:11464986.

NimitY,LawJ,DalyJW.Bindingof2",5"-dideoxyadenosinetobrainmembranes.ComparisontoP-siteinhibitionofadenylatecyclase.BiochemPharmacol.1982Oct15;31(20):3279-87.PMID:6983353.

ABOUT LKT LABS LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.