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LKT/7-(TRIETHYLSILYL)-BACCATIN III/T0090/25 mg

价格
¥27280.00
货号:T0090-25mg
浏览量:73
品牌:LKT Labs
服务
全国联保
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商品描述
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

7-Triethylsilyl-baccatinIIIisasyntheticintermediateinthesynthesisoftaxol.BaccatinhastrADItionallybeenassumedtobedevoidofactivity,althoughmanystudieshaveindicatedthatbaccatinexhibitsanticancerandimmunomodulatoryactivities.Baccatindecreasesthemitochondrialmembranepotentialandinducescaspase10-dependentapoptosisinavarietyofcancercelllines,resultingininhibitionofcellproliferation.Baccatinalsoincreasestubulinassemblyandinhibitstubulindisassembly,alteringmicrotubulepolymerization.Additionally,thiscompoundincreasespresentationofantigenonMHCIandIIreceptorsondendriticcellsinvitroandinvivo.

ProductInfo

CasNo.

115437-21-3

Purity

≥98%

Formula

C37H52O11Si

FormulaWt.

700.89

Appearance

WhitePowder

ShippingandStorage

StoreTemp

-20°C

ShipTemp

Ambient

Downloads

InfoSheet

T0090InfoSheetPDF

References

ChakravarthiBV,SujayR,KuriakoseGC,etal.Inhibitionofcancercellproliferationandapoptosis-inducingactivityoffungaltaxolanditsprecursorbaccatinIIIpurifiedfromendophyticFusariumsolani.CancerCellInt.2013Oct23;13(1):105.PMID:24152585.

LeeYH,LeeYR,KimKH,etal.BaccatinIII,asyntheticprecursoroftaxol,enhancesMHC-restrictedantigenpresentationindendriticcells.IntImmunopharmacol.2011Aug;11(8):985-91.PMID:21354357.

GeH,SpletstoserJT,YangY,etal.Synthesisofdocetaxelandbutitaxelanaloguesthroughkineticresolutionofracemicbeta-lactamswith7-O-triethylsilylbaccatinIII.JOrgChem.2007Feb2;72(3):756-9.PMID:17253791.

ChatterjeeSK,BarronDM,VosS,etal.BaccatinIIIinducesassemblyofpurifiedtubulinintolongmicrotubules.Biochemistry.2001Jun12;40(23):6964-70.PMID:11389612.

ABOUT LKT LABS LKT Laboratories is a biochemical supply company focused on the synthesis, purification, and isolation of small molecules for research applications. Its range of products exhibit known biological activities that have found uses in a wide array of research fields, especially cancer and neuroscience. These products include protein kinase inhibitors, ion channel modulators, and activators. LKT serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.