Zyagen/ULK1 Antibody/9783/1 Ea

价格
¥5900.00
货号:9783
浏览量:108
品牌:Zyagen
服务
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商品描述

Background

ULK1Antibody:ULK1,alsoknownasATG1,isakeyserine/threonineproteinkinaseprobablyactingatthemostupstreamstepofautophagosomeformation.KnockoutofULK1resultsinaseveredefectintheautophagypathway.ULK1ishighlyconservedamongeukaryotes,andaretheUnc-51-likekinases,ULK1andULK2inmammals.ULK1isubiquitouslyexpressedandinvolvedinautophagyinresponsetostarvation.ItisthetargetoftheTORkinasesignalingpathwaythatregulatesautophagythroughthecontrolofphosphorylationstatusofATG13.ULK1alsoplaysaroleearlyinneuronaldifferentiation.

 

Description
ULK1 Antibody
WesternblotanalysisofULK1inratbraintissuelysatewithULK1antibodyat1μg/mLin(A)theabsenceand(B)thepresenceofblockingpeptide.

 

 

 

 

 

 

 

 

 

 

 

Specifications

AdditionalNames
ULK1Antibody:Serine/threonine-proteinkinaseULK1,Unc-51-likekinase1,UNC51,Unc51.1,ATG1,ATG1A
Storage
ULK1antibodycanbestoredat4ËšCforthreemonthsand-20ËšC,stableforuptooneyear.
Reference

  • SuzukiK,KubotaY,SekitoT,etal.HierarchyofAtgproteinsinpre-autophagosomalstructureorganization.GenestoCells2007;12:209¨C18.
  • LeeEJandTournierC.Therequirementofuncoordinated51-likekinase1(ULK1)andULK2intheregulationofautophagy.Autophagy2011;7:689-95.
  • YanJ,KuroyanagiH,TomemoriT,etal.MouseULK2,anovelmemberoftheUNC-51-likeproteinkinases:uniquefeaturesoffunctionaldomains.Oncogene1999;18:5850¨C9.
  • BachM,LaranceM,JamesDE,etal.Theserine/threoninekinaseULK1isatargetofmultiplephosphorylationevents.Biochem.J.2011;440:283-91.]
Formulation
PhysicalState:Liquid 

Concentration:1mg/mL
ProteinGINumber
4507831
ProteinAccessionNumber
NP_003556
MolecularWeight
Predicted:116kDa 

Observed:105kDa
Disclaimer
Thisproductisforresearchuseonly.
TestedApplication
E,WB
BlockingPeptide
Cat.No.ZP-7335-ULK1Peptide
UserNote
Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher.
Conjugate
None
Purification
ULK1Antibodyisaffinitychromatographypurifiedviapeptidecolumn.
Clonality/Clone
ThisisapolyclonalULK1Antibody.
Isotype
IgG
Host
ULK1antibodywasraisedinrabbit.

Pleaseuseanti-rabbitsecondaryantibodies.
Specificity
Twoalternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified.ULK1antibodyispredictedtonotcross-reactwithULK2.
Immunogen
ULK1antibodywasraisedagainsta16aminoacidpeptidenearthecenterofhumanULK1.
Application
ULK1AntibodycanbeusedfordetectionofULK1byWesternblotat1μg/mL.
Buffer
ULK1AntibodyissuppliedinPBScontaining0.02%sodiumazide.
SpeciesReactivity
H,M,R

 

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