Zyagen/TFEB Antibody/9777/1 Ea

价格
¥6700.00
货号:9777
浏览量:112
品牌:Zyagen
服务
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商品描述

Background

TFEBAntibody:TheTranscriptionfactorEB(TFEB)isamemberinthebasichelix-loop-helixleucinezippersuperfamilyoftranscriptionfactorsthatistranslocatedinasubsetofrenaltumors.RecentstudieshaveshownthatlysosomalbiogenesisisregulatedbyTFEB,whichisinturnregulatedbythemammaliantargetofrapamycin(mTOR)complex1.OtherevidencesuggeststhatTFEBcoordinatesthemajorstepsoftheautophagicpathwaybydrivingtheexpressionofautophagyandlysosomalgenes.

 

Description
TFEB Antibody
WesternblotanalysisofTFEBinA549celllysatewithTFEBantibodyat(A)1and(B)2μg/mL.
TFEB Antibody
ImmunohistochemistryofTFEB(NT)inhumanlungtissuewithTFEB(NT)antibodyat2.5μg/mL.

 

 

 

 

 

 

 

 

 

 

 

Specifications

AdditionalNames
TFEBAntibody:TranscriptionfactorEB,TCFEB,BHLHE35,ALPHATFEB
Storage
TFEBantibodycanbestoredat4ËšCforthreemonthsand-20ËšC,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures.
Reference

  • CarrCSandSharpPA.Ahelix-loop-helixproteinrelatedtotheimmunoglobulinEbox-bindingproteins.Mol.CellBiol.1990;10:4384-8.
  • DavisIJ,HsiBL,ArroyoJD,etal.Cloningofanalpha-TFEBfusioninrenaltumorsharboringthet(6;11)(p21;q13)chromosometranslocation.Proc.Natl.Acad.Sci.USA2003;100:6051-6.
  • SardielloM,PalmieriM,diRonzaA,etal.Agenenetworkregulatinglysosomalbiogenesisandfunction.Science2009;325:473-7.
  • Pena-LlopisS,Vega-Rubin-de-CelisS,SchwartzJC,etal.RegulationofTFEBandV-ATPasesmymTORC1.EMBOJ.2011;30:3242-58]
Formulation
PhysicalState:Liquid 

Concentration:1mg/mL
ProteinGINumber
24307933
ProteinAccessionNumber
NP_009093
Disclaimer
Thisproductisforresearchuseonly.
TestedApplication
E,WB,IHC,IF
BlockingPeptide
Cat.No.-ZP-6801-TFEBPeptide
UserNote
Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher.
Conjugate
None
Purification
TFEBAntibodyisaffinitychromatographypurifiedviapeptidecolumn.
Clonality/Clone
ThisisapolyclonalTFEBAntibody.
Isotype
IgG
Host
TFEBantibodywasraisedinrabbit.

Pleaseuseanti-rabbitsecondaryantibodies.
Immunogen
TFEBantibodywasraisedagainstan18aminoacidsyntheticpeptideneartheaminoterminusofhumanTFEB.
Application
TFEBantibodycanbeusedfordetectionofTFEBbyWesternblotat1-2μg/mL.Antibodycanalsobeusedforimmunohistochemistrystartingat2.5μg/mL.Forimmunofluorescencestartat2.5μg/mL.
Buffer
TFEBAntibodyissuppliedinPBScontaining0.02%sodiumazide.
SpeciesReactivity
H

 

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