Zyagen/FOXO3 Antibody/9775/1 Ea

价格
¥6700.00
货号:9775
浏览量:109
品牌:Zyagen
服务
全国联保
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商品描述

Background

FOXO3Antibody:FOXO3isaubiquitouslyexpressed75kDaproteinmemberofasubfamilyoftheforkheadhomeoticgenefamilyoftranscriptionfactorsandshuttlesbetweenthecytoplasmandnucleus.FOXOtranscriptionfactorsarekeyplayersofcellfatedecisions,metabolism,stressresistance,tumorsuppressionandareregulatedbygrowthfactors,oxidativestressornutrientdeprivation.FOXO3isinvolvedwithmTORintheregulationofautophagyinskeletalmuscle,andactivatesproteindegradationinatrophyingmusclecells.FOXO3hasalsobeenimplicatedinseveralneurodegenerativedisordersincludingaging,neuromusculardisease,systemiclupuserythmatosus,strokeanddiabeticcomplications.

 

Description
FOXO3 Antibody
WesternblotanalysisofFOXO3inA-20celllysatewithFOXO3antibodyat(A)0.5and(B)1μg/mL.
FOXO3 Antibody
ImmunocytochemistryofFOXO3inA-20cellswithFOXO3antibodyat4μg/mL.

 

 

 

 

 

 

 

 

 

 

Specifications

AdditionalNames
FOXO3Antibody:ForkheadboxO3,FOXO2,FOXO3A,FKHRL1,FKHRL1P2
Disclaimer
Thisproductisforresearchuseonly.
UserNote
Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher.
Immunogen
FOXO3antibodywasraisedagainstan18aminoacidsyntheticpeptideneartheaminoterminusofhumanFOXO3.
Isotype
IgG
Clonality/Clone
ThisisapolyclonalFOXO3Antibody.
Conjugate
None
Formulation
PhysicalState:Liquid 

Concentration:1mg/mL
Purification
FOXO3Antibodyisaffinitychromatographypurifiedviapeptidecolumn.
Host
FOXO3antibodywasraisedinrabbit.

Pleaseuseanti-rabbitsecondaryantibodies.
Application
FOXO3antibodycanbeusedfordetectionofFOXO3byWesternblotat0.5-1μg/mL.Antibodycanalsobeusedforimmunocytochemistrystartingat4μg/mL.Forimmunofluorescencestartat20μg/mL.
TestedApplication
E,WB,ICC,IF
Buffer
FOXO3AntibodyissuppliedinPBScontaining0.02%sodiumazide.
BlockingPeptide
Cat.No.ZP-5813-FOXO3Peptide
Storage
FOXO3antibodycanbestoredat4ËšCforthreemonthsand-20ËšC,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures.
SpeciesReactivity
H,M,R
ProteinGINumber
42519916
ProteinAccessionNumber
NP_963853
Reference 

  • AndersonMJ,ViarsCS,CzekayS,etal.CloningandcharacterizationofthreehumanforkheadgenesthatcompriseanFKHR-likegenesubfamily.Genomics1998;47:187-99.
  • GreerELandBrunetA.FOXOtranscriptionfactorsattheinterfacebetweenlongevityandtumorsuppression.Oncogene2005;24:7410-25.
  • MammucariC,SchiaffinoS,andSandriM.DownstreamofAkt:FoxO3andmTORintheregulationofautophagyinskeletalmuscle.Autophagy2008;4:524-6.
  • ZhaoJ,BraultJJ,SchildA,etal.FoxO3coordinatelyactivatesproteindegradationbytheautophagic/lysosomalandproteasomalpathwaysinatrophyingmusclecells.CellMetab.2007;6:472-83.]

 

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