CYT-2415
Background
APRILAntibody:MembersintheTNFsuperfamilyregulateimmuneresponsesandinduceapoptosis.AnovelmemberintheTNFfamilywasrecentlyidentifiedbyseveralgroupsanddesignatedAPRIL(foraproliferation-inducingligand),TALL-2(forTNF-andApoL-relatedLeukocyte-expressedLigand2),andTRDL-1α(forTNFrelateddeathligand1α)inhumanandmouse.TworeceptorsforAPRILwererecentlyidentifiedanddesignatedTACIandBCMA.APRILstimulatesBandTcellproliferation,triggershumoralimmuneresponses,activatesNF-κB,andinducescelldeath.APRILanditscloserelativeofBlySandtheirreceptorsBCMAandTACIareinvolvedindiseasesofautoimmunityandcancer.
Description
WesternblotanalysisofAPRILexpressioninJurkatcellswithAPRILantibodyat1μg/mL(A),2μg/mL(B),and4μg/mL(C).
ImmunohistochemistryofAPRILinhumanprostatetissuewithAPRILantibodyat10μg/mL.
Specifications
AdditionalNames
APRIL(ED2)AdditionalNames
APRILAntibody:UserNote
Optimaldilutionsforeachapplicationtobedeterminedbytheresearcher.Isotype
IgGMolecularWeight
27kDaDisclaimer
Thisproductisforresearchuseonly.Formulation
PhysicalState:Liquid
Concentration:1mg/mLConjugate
NoneClonality/Clone
ThisisapolyclonalAPRILAntibody.Purification
APRILAntibodyisaffinitychromatographypurifiedviapeptidecolumn.Host
APRILantibodywasraisedinrabbit.
Pleaseuseanti-rabbitsecondaryantibodies.Immunogen
APRILantibodywasraisedagainstasyntheticpeptidecorrespondingtoaminoacidswithinaextracellulardomainofhumanAPRIL.Application
APRILantibodycanbeusedfordetectionofAPRILbyWesternblotat1-4μg/mL.A27kDabandwasdetected.Antibodycanalsobeusedforimmunohistochemistrystartingat10μg/mL.TestedApplication
E,WB,IHCBuffer
APRILAntibodyissuppliedinPBScontaining0.02%sodiumazide.BlockingPeptide
Cat.No.ZP-2415-APRIL(ED2)PeptideStorage
APRILantibodycanbestoredat4ËšCforthreemonthsand-20ËšC,stableforuptooneyear.Aswithallantibodiescareshouldbetakentoavoidrepeatedfreezethawcycles.Antibodiesshouldnotbeexposedtoprolongedhightemperatures.SpeciesReactivity
H,MProteinGINumber
4507599ProteinAccessionNumber
NP_003799Reference
- HahneM,KataokaT,SchroterM,etal.APRIL,anewligandofthetumornecrosisfactorfamily,stimulatestumorcellgrowth.JExpMed.1998;188(6):1185-90.
- ShuHB,HuWH,JohnsonH.TALL-1isanovelmemberoftheTNFfamilythatisdown-regulatedbymitogens.JLeukocBiol.1999;65(5):680-3.
- KellyK,ManosE,JensenG,etal.APRIL/TRDL-1,atumornecrosisfactor-likeligand,stimulatescelldeath.CancerRes.2000;60(4):1021-7.
- YuG,BooneT,DelaneyJ,etal.APRILandTALL-IandreceptorsBCMAandTACI:systemforregulatinghumoralimmunity.NatImmunol.2000;1(3):252-6.]
CYT-2415
Zyagen七五折促销
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上海起发实验试剂有限公司
2017-01-15 02:09:07
上海市
792
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Zyagen,Zyagen代理,Zyagen上海代理,Zyagen北京代理,Zyagen上海代理,Zyagen国内代理,Zyagen总代理,Zyagen一级代理
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Zyagen,Zyagen代理,Zyagen上海代理,Zyagen北京代理,Zyagen上海代理,Zyagen国内代理,Zyagen总代理,Zyagen一级代理
上海起发实验试剂有限公司American masterTech专业代理,具体产品信息欢迎电询:4006551678
美国Zyagen Laboratories公司位于加利福尼亚州的生物硅谷圣地亚哥,是一家著名的提供基因表达产品和服务的生物公司。从2000年到现在,在基因表达方面的研究及产品的推广一直处于全球地位。Zyagen Laboratories公司由一批训练有素的高水平的学者与研究人员,同时与发展中国家的科学家在生物制药,生物技术等方面有着广泛的合作。