Characteristics:

CHO-derived

Referenceslist:

• Interferon-betamodulatesproteinsynthesisinthecentralnervoussystem.Beyer,Susanne,etal.J.Neuroimmunol.2009Aug18;213:31-8
• Interferon-βattenuateslunginflammationfollowingexperimentalsubarachnoidhemorrhage.Cobelens,PieterM,etal.CritCare2010;14:R157
• Neuromodulationbyacytokine:interferon-betadifferentiallyaugmentsneocorticalneuronalactivityandexcitABIlity.Hadjilambreva,Gergana,etal.J.Neurophysiol.2005Feb;93:843-52
• Interferon-betafailstoprotectinamodeloftransientfocalstroke.Maier,CarolinaM,etal.Stroke2006Apr;37:1116-9
• ExperimentalNeuromyelitisOpticaInducesaTypeIInterferonSignatureintheSpinalCord.Oji,Satoru,etal.PLoSONE2016;11:e0151244
• ProteinkinaseCactivationmediatesinterferon-β-inducedneuronalexcitabilitychangesinneocorticalpyramidalneurons.Reetz,Olivia,etal.JNeuroinflammation2014;11:185
• ThelengthoftreatmentdetermineswhetherIFN-betapreventsoraggravatesexperimentalautoimmuneencephalomyelitisinLewisrats.Ruuls,SR,etal.J.Immunol.1996Dec15;157:5721-31
• ElevationinTypeIInterferonsInhibitsHCN1andSlowsCorticalNeuronalOscillations.Stadler,Konstantin,etal.Cereb.Cortex2014Jan;24:199-210
• Effectofinterferon-βonneuroinflammation,braininjuryandneurologicaloutcomeafterexperimentalsubarachnoidhemorrhage.Tiebosch,IvoACW,etal.NeurocritCare2013Feb;18:96-105

U-CyTech为干扰素提供基于CPE的抗病毒测定（AVA）测试，也称为细胞病变效应（CPE）抑制测定。在该体外生物测定中，将一个单位定义为将病毒感染的CPE降低50％的干扰素的量。将测试样品的抗病毒生物活性与国际或实验室标准制剂进行比较，并以国际单位（IU）或实验室单位（LU）/ ml表示。 人，大鼠和小鼠干扰素的生物活性分别通过人肺上皮细胞（HEp-2），大鼠胚胎细胞（RATEC）和小鼠成纤维细胞（L929）受到水泡性口腔炎病毒（VSV）攻击来测量。