Description:

TheWntsignalingpathwayisimportanttobothembryonicdevelopmentandtumOrigenesis.ß-Catenin,thecentralcomponentofthepathway,functionsasaco-factoroftheTCF/LEFfamilyoftranscriptionfactors. Together,theyactivatetranscriptionofWnttargetgenesbybindingtothepromotersofdownstreamtargetgenesinvolvedincellproliferation,survival,andmigration.Signosis’Wnt/ß-CateninsignalingpathwayCDNAplatearraycansimultaneouslymeasuretheexpressionof20+genesthatparticipateinthepathwayandcancomparethedifferencesintheexpressionofthesegenesindifferentsamples.

ApplicableGrid:

ListofApplicableGenes

1

2

3

4

5

6

7

8

9

10

11

12

A

Axin-2

Id2

NOS2

Axin-2

Id2

NOS2

Axin-2

Id2

NOS2

Axin-2

Id2

NOS2

B

beta-actin

LEF1

POU5F1

beta-actin

LEF1

POU5F1

beta-actin

LEF1

POU5F1

beta-actin

LEF1

POU5F1

C

beta-catenin

Met

PPARd

beta-catenin

Met

PPARd

beta-catenin

Met

PPARd

beta-catenin

Met

PPARd

D

c-JUN

MMP1

Sox9

c-JUN

MMP1

Sox9

c-JUN

MMP1

Sox9

c-JUN

MMP1

Sox9

E

c-myc

MMP7

Survivin

c-myc

MMP7

Survivin

c-myc

MMP7

Survivin

c-myc

MMP7

Survivin

F

CyclinD

MMP9

Tcf-1

CyclinD

MMP9

Tcf-1

CyclinD

MMP9

Tcf-1

CyclinD

MMP9

Tcf-1

G

FosL1

MMP26

uPAR

FosL1

MMP26

uPAR

FosL1

MMP26

uPAR

FosL1

MMP26

uPAR

H

beta-actin

nanog

VEGF

beta-actin

nanog

VEGF

beta-actin

nanog

VEGF

beta-actin

nanog

VEGF

Signosis基因表达  是利用来自基因的信息指导功能性基因产物合成的过程。这些产品通常是蛋白质。基因表达分析对于理解基因及其蛋白产物的功能，以及对影响基本生物学过程的复杂调控网络的清晰了解至关重要。Signosis  提供了许多用于基因表达研究的测定产品，包括用于监控由TF上调或下调的基因表达的cDNA板阵列，以及用于分析基因表达的单细胞PCR试剂盒，可直接分析细胞无需RNA分离即可进行裂解。 SARS-CoV-2实时PCR检测试剂盒单细胞基因表达分析印迹分析RNA的cDNA板阵列细胞裂解液的cDNA板阵列