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蚂蚁淘在线 / 品牌中心 / Signosis / Signosis/Cancer Stem Cell TF Activation Profiling Plate Array with Nuclear Extraction Kit/FA-1004-NE/1 Ea
商品描述
Description:
TranscriptionalregulationplaysacriticalroleinthecontrolofBIOLOGicalprocesses,andtranscriptionfactorshavebeenconsideredasmasterswitchesforcellfatedetermination.ThecancerstemcellparADIgmpostulatesthatdecontrolledtissue-specificstemcellsorProgenitorcellsareprecursorsforcancerbiogenesis.Cancerstemcellsareasubsetofcancercellswithinatumorthathavestemcell-likecharacteristics.DuringtumOrigenesis,deregulatedtranscriptionfactorexpressionoractivationcanpromoteabnormalself-renewal,proliferation,anddifferentiationofthecells.Forexample,OCT4,Sox2,KLF4,MycandNanoghavebeenshowntopossessthepowertoreprogramsomaticcellsintopluripotentcellsbyreactivatingpluripotentgenesandsilencingsomaticgenes.Understandingtheactivationpatternsofcancerstemcellrelatedtranscriptionfactorsinatumorcanhelptounderstandthetranscriptionalmechanismofcancerstemcellandprovidebetterapproachesfortargetingandeliminatingcancerstemcells.ApplicableGrid:
ListofApplicableTFs:
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | |
| A | Androgen | KLF4 | Snail | Androgen | KLF4 | Snail | Androgen | KLF4 | Snail | Androgen | KLF4 | Snail |
| B | AP1(Jun) | Myc | SOX2 | AP1(Jun) | Myc | SOX2 | AP1(Jun) | Myc | SOX2 | AP1(Jun) | Myc | SOX2 |
| C | AP2 | Nanog | SOX9 | AP2 | Nanog | SOX9 | AP2 | Nanog | SOX9 | AP2 | Nanog | SOX9 |
| D | CREB | NFkB1 | STAT3 | CREB | NFkB1 | STAT3 | CREB | NFkB1 | STAT3 | CREB | NFkB1 | STAT3 |
| E | ER | NKX3.1 | TBX3 | ER | NKX3.1 | TBX3 | ER | NKX3.1 | TBX3 | ER | NKX3.1 | TBX3 |
| F | FoxO3 | Oct-3/4 | Twist-1 | FoxO3 | Oct-3/4 | Twist-1 | FoxO3 | Oct-3/4 | Twist-1 | FoxO3 | Oct-3/4 | Twist-1 |
| G | Gli | p53 | WT1 | Gli | p53 | WT1 | Gli | p53 | WT1 | Gli | p53 | WT1 |
| H | HIF-1 | PRDM14 | Blank | HIF-1 | PRDM14 | Blank | HIF-1 | PRDM14 | Blank | HIF-1 | PRDM14 | Blank |
