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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
AmyloidOligomers(A11)AntibodyProperties Description Anti-AmyloidOligomers(A11)(RABBIT)Antibody-200-401-E88 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,Mouse,Rat Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 0.5mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.09%(w/v)SodiumAzide StABIlizer 50%(v/v)Glycerol GeneName APP RelevantLinks NCBI-NM_000484.3 |
AmyloidOligomers(A11)AntibodyDescription
Background
Amyloidmonomericproteinscansometimesoligomerizeintodestructiveamyloidfibrils.Amyloidogenicconformationsofnon-diseaserelatedproteinscanbecreatedbypartialproteinmisfoldingordenaturation.Manydegenerativediseasesareknowntoberelatedtotheaccumulationofmisfoldedproteinsasamyloidfibres.Theseincludetheamyloid-ßpeptideplaquesandtauneurofibrillarytanglesinsenileplaquesofAlzheimer’ssymptomology,thedepositionofa-synucleinintheLewybodiesofParkinson’sdisease,andaccumulationofpolyglutamine-containingaggregatesinHuntington’sdisease.
Synonyms
AmyloidOligomeraß,A11,AmyloidbetaA4protein,ABPP,APPI,Alzheimerdiseaseamyloidprotein,Cerebralvascularamyloidpeptide,PreA4,Proteasenexin-II,APP,A4,AD1
Immunogen
AmyloidOligomers(A11)Antibodywasproducedfromwholerabbitserumpreparedbyrepeatedimmunizationswithsyntheticmolecularmimicofsolubleoligomers.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AmyloidFibrils(OC)AntibodyissuitableforuseinIP,IFmicroscopy,IHC,ELISA,WB,andDotblot.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.
Purity/Specifity
Anti-AmyloidOligomers(A11)AntibodywaspurifiedbyProteinAchromatography.ABLASTanalysiswasusedtosuggestcross-reactivitywithAmyloidOligomers(A11)fromEukaryotes,Human,Mouse,andRatbasedon100%homologywiththeimmunizingsequence.Recognizesalltypesofamyloidoligomers.Appearstorecognizeapeptidebackboneepitopethatiscommontoamyloidoligomers,butisnotfoundinnativeproteins,amyloidogenicmonomerormatureamyloidfibrils.Cross-reactivitywithAmyloidOligomers(A11)fromothersourceshasnotbeendetermined.Neuroscienceresearch.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
