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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
AML1-ETOAntibodyProperties Description Anti-AML1-ETO(RABBBIT)Antibody-100-401-V33 Host Rabbit TargetSpecies Human KnownCrossReactivity Human Clonality PolyclonalIgG Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format Antiserum Label Unconjugated Buffer None Preservative 0.05%(w/v)SodiumAzideand0.05%ProClin300 StABIlizer None GeneName RUNX1 RelevantLinks UniProtKB-Q01196 GeneID-861 NCBI-NP_001001890 |
AML1-ETOAntibodyDescription
Background
ThisantibodyspecificallyrecognizestheAML1(RUNX1)(UniProtKB/Swiss-ProtentryQ01196)-ETO(RUNX1T1)(UniProtKB/Swiss-ProtentryQ06455)fusionproteinthatarisesduetoatranslocationbetweenchromosome8and22.Thistranslocationisoneofthemostfrequentkaryotypicabnormalitiesobservedinacutemyeloidleukaemia.Itproducesachimericalgenemadeupofthe5’-regionofAML1andthe3’-regionofETO.Thechimericalproteinisthoughttoassociatewiththenuclearcorepressor/histonedeacetylasecomplextoblockhematopoieticdifferentiation.Anti-AML1-ETOAntibodyisidealforresearchinCancerandGeneExpression.
Synonyms
Runt-relatedtranscriptionfactor1,Acutemyeloidleukemia1protein,Core-bindingfactorsubunitalpha-2,CBF-alpha-2,OncogeneAML-1,Polyomavirusenhancer-bindingprotein2alphaBsubunit,PEA2-alphaB,PEBP2-alphaB,SL3-3enhancerfactor1alphaBsubunit,SL3/AKVcore-bindingfactoralphaBsubunit
Immunogen
Anti-AML1-ETOAntibodywasproducedinrabbitsbyrepeatedimmunizationswithasyntheticpeptideofhumanAML1-ETO.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AML1-ETOAntibodyissuitableforChromatinImmunoprecipitation,ELISAandWesternBlots.Specificconditionsforreactivityshouldbeoptimizedbytheenduser. Expectabandapproximately80kDaintheappropriatecelllysateorextract.
Purity/Specifity
Anti-AML1-ETOAntibodyismonospecificantiserumprocessedbydelipidationanddefibrinationfollowedbysterilefiltration.ThisproductreactswithhumanAML1-ETO. CrossreactivitywithAML1-ETOfromothersourcesisnotknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
