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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
Alpha-2-MacroglobulinAntibodyProperties Description Anti-alpha-2-MACROGLOBULIN(GOAT)Antibody-200-101-207-0100 Host Goat TargetSpecies Human KnownCrossReactivity human Clonality Polyclonal Application ELISA:1:80,000-1:400,000 WesternBlot:1:2,000-1:20,000 Immunohistochemistry:UserOptimized OtherDilution:UserOptimized SpeciesofOrigin goat PhysicalState Lyophilized ShippingCondition Ambient Format IgG Label Unconjugated Concentration 1.0mg/mlbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 ReconstitutionVolume 100µL ReconstitutionBuffer Restorewithdeionizedwater(orequivalent) Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName A2M RelevantLinks UniProtKB-P01023 NCBI-P01023.3 GeneID-2 |
Alpha-2-MacroglobulinAntibodyDescription
Background
Alpha-2-MacroglobulindetectsMacroglobulin.Alpha-2-MACROGLOBULINisalargeplasmaproteinfoundintheblood.Itisproducedbytheliver,andisamajorcomponentofthealpha-2bandinproteinelectrophoresis.Alpha2-Macroglobulinisthelargestmajornonimmunoglobulinproteininplasma.Thealpha2-macroglobulinmoleculeissynthesizedmainlyinliver,butalsolocallybymacrophages,fibroblasts,andadrenocorticalcells.Alpha2macroglobulinactsasanantiproteaseandisabletoinactivateanenormousvarietyofproteinases.Itfunctionsasaninhibitoroffibrinolysisbyinhibitingplasminandkallikrein.Itfunctionsasaninhibitorofcoagulationbyinhibitingthrombin.Alpha2-macroglobulinmayactasacarrierproteinbecauseitalsobindstonumerousgrowthfactorsandcytokines,suchasplatelet-derivedgrowthfactor,basicfibroblastgrowthfactor,TGF-ß,insulin,andIL-1ß.Nospecificdeficiencywithassociateddiseasehasbeenrecognized,andnodiseasestateisattributedtolowconcentrationsofAlpha2macroglobulin.Theconcentrationofalpha2macroglobulinrises10-foldormoreinthenephroticsyndromewhenotherlowermolecularweightproteinsarelostintheurine.Thelossofalpha2macroglobulinintourineispreventedbyitslargesize.Thenetresultisthatalpha2macroglobulinreachesserumlevelsequaltoorgreaterthanthoseofalbumininthenephroticsyndrome,whichhastheeffectofmaintainingoncoticpressure.Antialpha-2-macroglobulinisidealforinvestigatorsinvolvedinserumcomponentproteinresearch.
Synonyms
goatanti-Alpha-2-MacroglobulinAntibody,A2Mantibody,Alpha2Mantibody,Alpha2Mantibody,CPAMD5antibody,DKFZp779B086antibody,FWP007antibody,S8637antibody
Immunogen
a2-Macroglobulin[HumanPlasma]
ImmunogenType
NativeProtein
StorageCondition
Storevialat4°Cpriortorestoration.Forextendedstoragealiquotcontentsandfreezeat-20°Corbelow.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-alpha-2-macroglobulinantibodyissuitableforELISA,WesternBlotandImmunohistochemistryapplications.Anti-alpha-2-MACROGLOBULINantibodyshouldbeoptimizedbytheenduserforthespecificreactiveconditions.
Purity/Specifity
Anti-alpha-2-MACROGLOBULINisanIgGfractionantibodypurifiedfrommonospecificantiserumbyamulti-stepprocesswhichincludesdelipidation,saltfractionationandionexchangechromatographyfollowedbyextensivedialysisagainstthebufferstatedabove. Assaybyimmunoelectrophoresisresultedinasingleprecipitinarcagainstanti-GoatSerumaswellaspurifiedandpartiallypurifieda2-Macroglobulin[HumanPlasma]. Crossreactivityagainsta2-Macroglobulinfromothersourcesisunknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
