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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
AlphaSynucleinphosphoS129AntibodyProperties Description Anti-alphaSynucleinpS129(Rabbit)Antibody-612-401-C70 Host Rabbit TargetSpecies Rat KnownCrossReactivity rat Clonality Polyclonal Application ELISA:1:10,000 WesternBlot:1:1000 PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.01MHEPES,0.15MSodiumChloride,pH7.5 StABIlizer 0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol GeneName SNCA RelevantLinks NCBI-NP_062042.1 UniProtKB-P37377 GeneID-29219 |
AlphaSynucleinphosphoS129AntibodyDescription
Background
AlphaSynucleinpS129AntibodydetectsAlpha-synucleinphosphorylatedatS129.Alpha-synucleinisapresynapticneuronalproteinthatisthoughttobeinvolvedintheformationofSNAREcomplexes.Mostsignificantly,aggregatedalpha-synucleinisoneofthemajorcomponentsfoundintheLewybodiesthatoccurinParkinson’sdisease(PD)andotherneurodegenerativedisorders.Mutationofthealpha-synucleingeneisassociatedwithfamilialformsofPD.Recentevidencesuggeststhatphosphorylationofalpha-synucleinatSer129playsaroleintheformationofinclusionsinPD.Anti-Alpha-synucleinantibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
Non-AbetacomponentofADamyloid,Non-A4componentofamyloidprecursor
Immunogen
Anti-AlphaSynucleinpS129AntibodywasproducedbyrepeatedimmunizationswithasyntheticphosphopeptidecorrespondingtoaminoacidresiduessurroundingSer129.
ImmunogenType
Peptide
PostTranslationalModification
Phosphorylation
StorageCondition
Storevialat-20°Cpriortoopening.Thisproductisstableat4°Casanundilutedliquid.Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow.Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
AlphaSynucleinpS129antibodyissuitableforuseinELISA,WesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately15kDainsizecorrespondingtothealphasynucleinproteinphosphorylatedatSer129intheappropriatecelllysateorextract.
Purity/Specifity
Anti-AlphaSynucleinpS129AntibodyisdirectedagainstratAlpha-synucleinphosphorylatedatS129.Theantibodywaspreparedfrommonospecificantiserumbyimmunoaffinitychromatographyusingphosphopeptidecoupledtoagarosebeadsfollowedbysolidphaseadsorption(s)againstnon-phosphopeptideandnon-specificpeptidetoremoveanyunwantedreactivities.Assaybyimmunoelectrophoresisresultedinasingleprecipitinarcagainstanti-RabbitSerum.ThisantibodyisspecificforphosphorylatedAlpha-synuclein.Minimalreactivityoccursagainstnon-phosphorylatedAlpha-synuclein.ReactivityagainstAlpha-synucleinoccursfromratsources.Reactivityisexpectedagainstthefollowingspeciesbasedon100%sequencehomology:bovine,canine,human,mouse,andnon-humanprimate.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
