品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
AlphaInternexinAntibodyProperties Description Anti-AlphaInternexin(Chicken)Antibody-200-901-D04 Host Chicken TargetSpecies Rat KnownCrossReactivity rat,mouse,human Clonality Polyclonal Application PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide GeneName INA RelevantLinks UniProtKB-P23565 GeneID-24503 UniProtKB-P23565.2 |
AlphaInternexinAntibodyDescription
Background
Anti-AlphaInternexinantibodyrecognizesalpha-internexinwhichisaClassIVintermediatefilamentoriginallydiscoveredasitco-purifieswithotherneurofilamentsubunits.Alpha-internexinisrelatedtobutdistinctfromthebetterknownneurofilamenttripletproteins,NF-L,NF-MandNF-H,havingsimilarproteinsequencemotifsandasimilarintronorganization.Itisexpressedonlyinneuronsandinlargeamountsearlyinneuronaldevelopment,butisdown-regulatedinmanyneuronsasdevelopmentproceeds.Manyclassesofmatureneuronscontainalpha-internexininadditiontoNF-L,NF-MandNF-H.Insomematureneuronsalpha-internexinistheonlyneurofilamentsubunitexpressed.Antibodiestoalpha-internexinarethereforeuniqueprobestostudyandclassifyneuronaltypesandfollowtheirprocessesinsectionsandintissueculture.Inaddition,recentstudiesshowamarkedup-regulationofalpha-internexinduringneuronalregeneration.Theuseofantibodiestothisproteininthestudyofbraintumorshasnotbeenexaminedtodate,butislikelytobeofinterest.RecentlyCairnsetal.usedthisantibodytoshowthatalpha-internexinisanabundantcomponentoftheinclusionsofneurofilamentinclusionbodydisease(NFID),aserioushumanneurodegenerativedisorder.Theantibodywasalsousedtoconfirmthepresenceofcirculatingauto-antibodiestoalpha-internexinintheseraofsomepatientswithendocrineautoimmunity,aswellasinsomenormalindividuals.Anti-AlphaInternexinantibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
AlphaINX,internexin,NF-66,NEF5
Immunogen
Anti-AlphaInternexinAntibodywasproducedbyrepeatedimmunizationswithrecombinantratalphainternexin.
ImmunogenType
RecombinantProtein
StorageCondition
Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AlphaInternexinantibodyissuitableforuseinELISA,WesternBlottingandIF.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately66kDainsizecorrespondingtothealphainternexinproteininWesternblotsintheappropriatecelllysateorextract.Minorbandsat~150kareprobablycovalentdimersandbandsat~50krepresentalpha-internexinbreakdownproducts.
Purity/Specifity
Anti-AlphaInternexinAntibodyisdirectedagainstratAlphaInternexinproteins.TheantibodywaspurifiedfromchickeneggsasanIgYfraction.Thisantibodyisdirectedagainstratalphainternexinprotein.Reactivityisexpectedfrommouseandhuman.CrossreactivitywithAlphaInternexinfromotherspecieshasnotbeendetermined
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitABIlityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
