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苏州工业园区生物纳米园A4#216
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商品描述
AlphaInternexinAntibodyProperties Description Anti-AlphaInternexin(Mouse)Antibody-900-301-D04 Host Mouse TargetSpecies Rat KnownCrossReactivity human,mouse,rat Clonality MonoclonalID2 Application PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide GeneName INA RelevantLinks UniProtKB-P23565 GeneID-24503 UniProtKB-P23565.2 |
AlphaInternexinAntibodyDescription
Background
Anti-AlphaInternexinantibodyrecognizesalpha-internexinwhichisaClassIVintermediatefilamentoriginallydiscoveredasitco-purifieswithotherneurofilamentsubunits.Alpha-internexinisrelatedtobutdistinctfromthebetterknownneurofilamenttripletproteins,NF-L,NF-MandNF-H,havingsimilarproteinsequencemotifsandasimilarintronorganization.Itisexpressedonlyinneuronsandinlargeamountsearlyinneuronaldevelopment,butisdown-regulatedinmanyneuronsasdevelopmentproceeds.Manyclassesofmatureneuronscontainalpha-internexininadditiontoNF-L,NF-MandNF-H.Insomematureneuronsalpha-internexinistheonlyneurofilamentsubunitexpressed.Antibodiestoalpha-internexinarethereforeuniqueprobestostudyandclassifyneuronaltypesandfollowtheirprocessesinsectionsandintissueculture.Inaddition,recentstudiesshowamarkedup-regulationofalpha-internexinduringneuronalregeneration.Theuseofantibodiestothisproteininthestudyofbraintumorshasnotbeenexaminedtodate,butislikelytobeofinterest.RecentlyCairnsetal.usedthisantibodytoshowthatalpha-internexinisanabundantcomponentoftheinclusionsofneurofilamentinclusionbodydisease(NFID),aserioushumanneurodegenerativedisorder.Theantibodywasalsousedtoconfirmthepresenceofcirculatingauto-antibodiestoalpha-internexinintheseraofsomepatientswithendocrineautoimmunity,aswellasinsomenormalindividuals.Anti-AlphaInternexinantibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
mouseanti-AlphaInternexinAntibody,AlphaINX,internexin,NF-66,NEF5
Immunogen
Anti-AlphaInternexinAntibodywasproducedbyrepeatedimmunizationswithrecombinantratalphainternexin.
ImmunogenType
RecombinantProtein
StorageCondition
Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AlphaInternexinantibodyissuitableforuseinELISA,WesternBlotting,IHCandIF.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately66kDainsizecorrespondingtoalphainternexinproteinsintheappropriatecelllysateorextract.
Purity/Specifity
Anti-AlphaInternexinAntibodyisdirectedagainstratAlphaInternexin.TheantibodyisatotalIgGfractionfromconcentratedclarifiedcellculturesupernate.Anti-AlphaInternexinantibodycanbeusedonformalin-fixedcellsintissueculture,cryostatsections,andWesternblotting.TheepitoperecognizedbytheID2cloneisintheC-terminalnon-helicalextensionoftheproteinandisunusuallyresistanttoaldehydefixation,sothatthisantibodyisidealforstudiesofparaffinembeddedformalinfixedhistologicalsections.Reactivityisexpectedagainsthumanandmouse.Crossreactivityfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitABIlityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
