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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
AIMAntibodyProperties Description Anti-AIM(RABBIT)Antibody-600-401-X88 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1.0mg/mlbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName CD5L RelevantLinks UniProtKB-O43866 GeneID-922 NCBI-AAD01446 |
AIMAntibodyDescription
Background
Apoptosisinhibitorofmacrophages(AIM)isamemberofthescavengerreceptorcysteine-richdomainsuperfamily(SRCR-SF)initiallyidentifiedasaninducIBLecellsurfaceligandofCD5.ItwasshownthatAIMfunctionsinthethymusastheinducerofresistancetoapoptosiswithinCD4+/CD8+thymocytesandasthesupporteroftheviabilityofthesecellsbeforethymicselection.AIMwasalsoshowntosupportmacrophagesurvivalandenhancetheirphagocyticfunction.MorerecentexperimentsusingrecombinantAIMsignificantlyinhibitedapoptosisofNKTandTcellsobtainedfromC.parvum-stimulatedliversinvitro,suggestingthatAIMfunctionstoinduceresistancetoapoptosisinthesecellsandsupportshostdefenseagainstinflammationduringinfection.
Synonyms
AIMAntibody,AIM,API6,PRO229,Spalpha,SP-ALPHA,UNQ203/PRO229,CD5antigen-like,CT-2
Immunogen
Anti-AIMantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha13aminoacidsyntheticpeptideneartheC-terminusofhumanAIM.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AIMAntibodyhasbeentestedforuseinELISA,WesternBlottingandImmunohistochemistry.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately38kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-AIMAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAIMfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
