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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
AGER/RAGEAntibodyProperties Description Anti-AGER/RAGE(RABBIT)Antibody-600-401-P67 Host Rabbit KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application WesternBlot:0.5µg/mL Immunohistochemistry:1:100-1:500 PhysicalState Lyophilized ShippingCondition Ambient Format IgG Label Unconjugated Concentration 0.5mg/mLbyUVabsorbanceat280nm Buffer 0.9mgNaCl,0.2mgNa2HPO4,0.05mgNaN3 ReconstitutionVolume 250µL ReconstitutionBuffer Restorewithdeionizedwater(orequivalent) Preservative 0.05mgThimerosal StABIlizer 5mgBSA GeneName AGER RelevantLinks UniProtKB-Q15109 GeneID-177 NCBI-NP_001127.1 |
AGER/RAGEAntibodyDescription
Background
Thereceptorforadvancedglycationendproducts(RAGE)isamulti-ligandmemberoftheimmunoglobulinsuperfamilyofcellsurfacemolecules.Itinteractswithdistinctmoleculesimplicatedinhomeostasis,developmentandinflammation,andcertaindiseasessuchasdiabetesandAlzheimer"sdisease.RAGEisalsoacentralcellsurfacereceptorforamphoterinandEN-RAGE.RAGEisassociatedwithsustainedNF-kappaBactivationinthediabeticmicroenvironmentandhasacentralroleinsensoryneuronaldysfunction.Moreover,RAGEpropagatescellulardysfunctioninseveralinflammatorydisordersanddiabetes,anditalsofunctionsasanendothelialadhesionreceptorpromotingleukocyterecruitment.Thisantibodyissuitableforresearchersinterestedinneuroscienceresearch.
Synonyms
Receptorforadvancedglycosylationendproducts,
Immunogen
AGER/RAGEaffinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaninternalregionofhumanRAGE.
ImmunogenType
Peptide
StorageCondition
Storevialat4°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-RAGEisusefulforImmunohistochemistry-P,-F,andWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandapproximately~42.8kDacorrespondingtotheappropriatecelllysateorextract.
Purity/Specifity
Anti-RAGEantibodyisdirectedagainsthumanRAGEprotein. Theproductwasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification. ABLASTanalysiswasusedtosuggestreactivitywiththisproteinfromhuman,mouse,andratbasedonhomologyfortheimmunogensequence. CrossreactivitywithRAGEfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
