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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
ADIponectinAntibodyProperties Description Anti-Adiponectin(RABBIT)Antibody-600-401-G73 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,Mouse,Rat Clonality Polyclonal Application WesternBlot:1ug/mL PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide GeneName ADIPOQ RelevantLinks NCBI-NP_004788 UniProtKB-Q15848 GeneID-9370 |
AdiponectinAntibodyDescription
Background
Adiponectionantibodydetectshumanadiponectin.Adiposetissueofanorganismplaysamajorroleinregulatingphysiologicandpathologicprocessessuchasmetabolismandimmunitybyproducingandsecretingavarietyofbioactivemoleculestermedadipokines.Onehighlyconservedfamilyofadipokinesisadiponectin/ACRP30anditsstructuralandfunctionalparalogs,theC1q/tumornecrosisfactor-alpha-relatedproteins(Ctrps)1-7.UnliketheCTRPs,whichareexpressedinawidevarietyoftissues,adiponectinisreportedtobeexpressedexclusivelybydifferentiatedadipocytes.Theseproteinsarethoughttoactmainlyonliverandmuscletissuetocontrolglucoseandlipidmetabolism.AnanalysisofthecrystalstructureofadiponectinrevealedastructuralandevolutionarylinkbetweenTNFandC1q-containingproteins,suggestingthattheseproteinsarosefromacommonancestralinnateimmunitygene.Itispresentinhighlevelsinnormalhumanplasma,butisreducedinobesesubjectsandofteninthosewithincreasedinsulinresistanceandtype2diabetes,suggestingthatadiponectinmaybeausefulpharmacologicaltargetinvariousmetabolicdiseases.Anti-Adiponectinantibodiesareidealforinvestigatorsinvolvedinglucoseengerymetabolismandapolipoproteinresearch.
Synonyms
ACDC,ACRP30,APM1,GBP28
Immunogen
AdiponectinAntibodywasproducedfromwholerabbitserumpreparedbyrepeatedimmunizationswithapeptidenearthen-terminusofhumanadiponectin.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AdiponectinAntibodyissuitableforuseinE,WB,andIHC.Expectabandapproximately~26.4kDaonspecificlysates.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.
Purity/Specifity
Anti-AdiponectinAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.ABLASTanalysiswasusedtosuggestcross-reactivitywithAdiponectinwithHuman,MouseandRatbasedon100%homologywiththeimmunizingsequence.Cross-reactivitywithAdiponectinfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitABIlityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
