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苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
ABCB1AntibodyProperties Description Anti-ABCB1(RABBIT)Antibody-600-401-967 Host Rabbit TargetSpecies Human KnownCrossReactivity human,monkey,dog,mouse,rat Clonality Polyclonal Application ELISA:1:10,000-1:50,000 WesternBlot:1:200-1:2,000 Immunohistochemistry:UserOptimized OtherDilution:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1.0mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName ABCB1 RelevantLinks GeneID-5243 NCBI-42741659 UniProtKB-P08183 |
ABCB1AntibodyDescription
Background
Thisantibodyisdesigned,produced,andvalidatedaspartofacollaborationbetweenRocklandandtheNationalCancerInstitute(NCI)andissuitableforCancer,ImmunologyandNuclearSignalingresearch.ATP-BindingCassetteSub-FamilyBMember1(ABCB1,alsonamedP-glycoprotein)isaplasmamembrane-associatedmultidrugtransporterthatutilizestheenergyofATPhydrolysistopumptoxicxenobioticsoutofcells.UniquefeaturesofABCB1areitsverybroadsubstratespecificityanditsbasalATPaseactivityintheabsenceoftransportsubstrates.HumanABCB1playsanimportantroleinabsorption,distribution,metabolism,excretionandtoxicityofpharmacologicallyrelevantdrugs.ItisresponsIBLefordecreaseddrugaccumulationinmultidrug-resistantcellsandoftenmediatesthedevelopmentofresistancetoanti-cancerdrugs.Thisproteinalsofunctionsasatransporteracrosstheblood-brainbarrier.
Synonyms
rabbitanti-ABCB1Antibody,ABCB1,ABCB-1,ATPbindingcassettesubfamilyBMDR/TAPmember1antibody,CD243antibody,CD243antigenantibody,CLCSantibody,GP170antibody,MDR1antibody
Immunogen
Thisaffinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacids262-277ofhumanABCB1protein.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
ThisaffinitypurifiedantibodyhasbeentestedforuseinELISAandwesternblot.
Purity/Specifity
Thisaffinity-purifiedantibodyisdirectedagainsthumanABCB1protein.Theproductwasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography. ABLASTanalysiswasusedtosuggestcrossreactivitywithABCB1proteinfromhuman,monkey,dog,mouse,andratbasedon100%homologywiththeimmunizingsequence. Reactivityagainsthomologuesfromothersourcesisnotknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
