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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
ABCA4RimProteinAntibodyProperties Description Anti-ABCA4(RimProtein)(Mouse)MonoclonalAntibody-200-301-D05 Host Mouse TargetSpecies Bovine KnownCrossReactivity bovine,human,mouse,Xenopus Clonality Monoclonal3F4IgG Application PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.01MHEPES,0.15MSodiumChloride,pH7.5 StABIlizer 0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol GeneName ABCA4 RelevantLinks UniProtKB-O35600 GeneID-11304 NCBI-NP_776646.1 |
ABCA4RimProteinAntibodyDescription
Background
ABCA4antibodydetectsABCA4(ATP-bindingcassette,sub-familyA(ABC1),member4,RimProtein)amemberofthesuperfamilyofATP-bindingcassette(ABC)transporters.ABCproteinstransportvariousmoleculesacrossextra-andintracellularmembranes.ABCA4isaretina-specificABCtransporterwithN-retinylidene-PEasasubstrate.Itisexpressedexclusivelyinretinaphotoreceptorcells,indicatingthegeneproductmediatestransportofanessentialmoleculeacrossthephotoreceptorcellmembrane.MutationsinthisgenearefoundinpatientsdiagnosedwithStargardtdiseaseandareassociatedwithretinitispigmentosa-19andage-relatedmaculardegeneration.DefectsinABCA4arethecauseofStargardtdiseasetype1(STGD1).STGDisoneofthemostfrequentcausesofmaculardegenerationinchildhood.DefectsinABCA4arealsoknowntocausefundusflavimaculatus(FFM),age-relatedmaculardegenerationtype2(ARMD2)andcone-roddystrophytype3(CORD3).Anti-ABCA4antibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
Retinal-specificATP-bindingcassettetransporter,ATP-bindingcassettesub-familyAmember4,RIMABCtransporter
Immunogen
Anti-ABCA4antibodywasproducedbyrepeatedimmunizationswithpartiallypurifiedbovine220-kDadiscrimprotein.
ImmunogenType
NativeProtein
StorageCondition
Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-ABCA4antibodyissuitableforuseinELISA,WesternBlottingandIHC.Specificconditionsshouldbeoptimizedbytheenduser.Expectabandof~250kDainsizecorrespondingtoABCA4proteinsintheappropriatecelllysateorextract.
Purity/Specifity
Anti-ABCA4antibodyisdirectedagainstbovineABCA4RimProtein.TheantibodywasProteinGpurifiedfromculturesupernatant.Reactivityisexpectedagainsthuman,mouseandXenopus.Cross-reactivitywithABCA4fromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
