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苏州工业园区生物纳米园A4#216
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商品描述
5-LipoxygenasephosphoS523AntibodyProperties Description Anti-5-LipoxygenasepS523(Rabbit)Antibody-600-401-D03 Host Rabbit TargetSpecies Human KnownCrossReactivity human,rat,mouse Clonality Polyclonal Application ELISA:1:10,000 WesternBlot:1:1000 PhysicalState Liquid ShippingCondition DryIce Format IgG Label Unconjugated Buffer 0.01MHEPES,0.15MSodiumChloride,pH7.5 StABIlizer 0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol GeneName ALOX5 RelevantLinks UniProtKB-P09917 GeneID-240 UniProtKB-P09917.2 |
5-LipoxygenasephosphoS523AntibodyDescription
Background
5-LipoxygenasepS523antibodyrecognizestheenzyme5-lipoxygenase(5-LO)whichplaysakeyroleinregulatingtheproductionofleukotrienes(LTs).OverproductionofLTscontributestoseveraldiseases,mostnotablychronicinflammatorydiseases,includingasthma,fibrosisandatherosclerosis.Recentworkhasdemonstratedthattheactivityof5-LOisregulatedbyPKAphosphorylationofserine-523in5-LO.Undernormalconditions,thisphosphorylationmaybeimportantinlimitinginflammation.AbnormalsignalingthroughcAMPandPKA,then,couldcontributetoavarietyofdiseases,includingthosecharacterizedbychronicinflammation.Thephospho-specificantibodytoSer523on5-LOisthuslikelytoprovideavaluabletoolforstudiesoftheroleof5-LOregulationindiseasessuchasasthma,fibrosisandatherosclerosis.Anti-5-LipoxygenasepS523antibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
Arachidonate5-lipoxygenase,5-LO
Immunogen
Anti-5-LipoxygenasepS523Antibodywasproducedbyrepeatedimmunizationswithsyntheticphospho-peptidecorrespondingtoaminoacidresiduessurroundingSer523.
ImmunogenType
Peptide
PostTranslationalModification
Phosphorylation
StorageCondition
Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-5-LipoxygenasepS523antibodyissuitableforuseinWesternBlottingandELISA.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately80kDacorrespondingtothe80kDa5-LOproteinsphosphorylatedatSer523.
Purity/Specifity
Anti-5-LipoxygenasepS523Antibodyisdirectedagainsthuman5-LipoxygenasephosphorylatedatS523.Theantibodyisaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.Reactivityisexpectedfromthefollowingspeciesbasedon100%sequencehomology:nonhumanprimates.Crossreactivitywith5-LipoxygenasepS523fromotherspecieshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
