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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
ArtemisAntibodyPropertiesDescription Anti-HumanARTEMIS(DCLRE1CDNAcross-linkrepair1C)[GOAT]Antibody-600-101-293 Host Goat TargetSpecies Human KnownCrossReactivity human Clonality Polyclonal Application ELISA:1:10,000-1:20,000 WesternBlot:1:500-1:2,000 Immunohistochemistry:1:1,000 OtherDilution:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1.2mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName DCLRE1C RelevantLinks UniProtKB-Q96SD1 NCBI-76496495 GeneID-64421 |
ArtemisAntibodyDescription
Background
ArtemishasaroleinTandBlymphocyteimmunodeficiencyandinpredispositiontolymphomathroughtheNHEJpathwayofDNArepair.DNA-PKcsregulatesArtemisbybothphosphorylationandcomplexformationtopermitenzymaticactivitiesthatarecriticalforthehairpin-openingstepofV(D)Jrecombinationandforthe5"and3"overhangprocessinginnon-homologousDNAendjoining.
Synonyms
goatanti-ArtemisAntibody,A-SCIDantibody,ASCIDproteinantibody,proteinArtemisantibody,DCLRE1Cantibody,DCLRE1C,DNAcrosslinkrepair1Cantibody,ASCID,SCIDA,SNM1C
Immunogen
Thisaffinitypurifiedantibodywaspreparedfromwholegoatserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingaa482-495ofHumanARTEMIS(DCLRE1CDNAcross-linkrepair1C).
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
ThisaffinitypurifiedantibodyhasbeentestedforuseinELISA,immunohistochemistryandwesternblotting. Reactivityinotherimmunoassaysisunknown.Thisantibodydetectsabandofapproximately90kDa(predictedmolecularweight:78kDa).
Purity/Specifity
Thisisanaffinitypurifiedantibodyproducedbyimmunoaffinitychromatographyusingtheimmunizingpeptideafterimmobilizationtoasolidphase.Thisantibodydetectsabandoftheappropriatesizeinanumberofdifferentcelllines.However,itdoesnotdetectabandincelllinesthatdonotexpressartemis,suchasthecelllineCJ(seefigure)andinanhTERTline(notshown).
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.